Reviews:

Antitumor Activity with CYP17 Blockade Indicates That Castration-Resistant Prostate Cancer Frequently Remains Hormone Driven

Gerhardt Attard, Alison H.M. Reid, David Olmos, and Johann S. de Bono
Cancer Res 2009 69: 4937-4940. Published Online First June 9, 2009. doi: 10.1158/0008-5472.CAN-08-4531 [Abstract] [Full Text] [PDF]  

Bispecific T-Cell Engaging Antibodies for Cancer Therapy

Patrick A. Baeuerle and Carsten Reinhardt
Cancer Res 2009 69: 4941-4944. Published Online First June 9, 2009. doi: 10.1158/0008-5472.CAN-09-0547 [Abstract] [Full Text] [PDF]  

Therapeutic Potential of "Rexinoids" in Cancer Prevention and Treatment

Takemi Tanaka and Luigi M. De Luca
Cancer Res 2009 69: 4945-4947. Published Online First June 9, 2009. doi: 10.1158/0008-5472.CAN-08-4407 [Abstract] [Full Text] [PDF]  

Perspective:

Cancer Genome Sequencing—An Interim Analysis

Edward J. Fox, Jesse J. Salk, and Lawrence A. Loeb
Cancer Res 2009 69: 4948-4950. Published Online First June 9, 2009. doi: 10.1158/0008-5472.CAN-09-1231 [Abstract] [Full Text] [PDF]  

Meeting Report:

Breast Cancer Metastasis: Challenges and Opportunities

Jing Lu, Patricia S. Steeg, Janet E. Price, Savitri Krishnamurthy, Sendurai A. Mani, James Reuben, Massimo Cristofanilli, Gabriela Dontu, Luc Bidaut, Vicente Valero, Gabriel N. Hortobagyi, and Dihua Yu
Cancer Res 2009 69: 4951-4953. Published Online First May 26, 2009. doi: 10.1158/0008-5472.CAN-09-0099 [Full Text] [PDF]  

Priority Reports:

Endogenous Tumor Suppression Mediated by PTEN Involves Survivin Gene Silencing

Minakshi Guha, Janet Plescia, Irwin Leav, Jing Li, Lucia R. Languino, and Dario C. Altieri
Cancer Res 2009 69: 4954-4958. Published Online First May 26, 2009. doi: 10.1158/0008-5472.CAN-09-0584 [Abstract] [Full Text] [PDF]  

Infrequent Detection of Germline Allele-Specific Expression of TGFBR1 in Lymphoblasts and Tissues of Colon Cancer Patients

Kishore Guda, Leanna Natale, James Lutterbaugh, Georgia L. Wiesner, Susan Lewis, Stephan M. Tanner, Jerneja Tomsic, Laura Valle, Albert de la Chapelle, Robert C. Elston, Joseph Willis, and Sanford D. Markowitz
Cancer Res 2009 69: 4959-4961. Published Online First June 9, 2009. doi: 10.1158/0008-5472.CAN-09-0225 [Abstract] [Full Text] [PDF]  

Cell, Tumor, and Stem Cell Biology:

Activation of Rap1 Promotes Prostate Cancer Metastasis

Candice L. Bailey, Patrick Kelly, and Patrick J. Casey
Cancer Res 2009 69: 4962-4968. Published Online First May 26, 2009. doi: 10.1158/0008-5472.CAN-08-4269 [Abstract] [Full Text] [PDF] Supplementary Data  

HOXA13 Promotes Cancer Cell Growth and Predicts Poor Survival of Patients with Esophageal Squamous Cell Carcinoma

Zhen-Dong Gu, Lu-Yan Shen, Hua Wang, Xiao-Mei Chen, Yong Li, Tao Ning, and Ke-Neng Chen
Cancer Res 2009 69: 4969-4973. Published Online First June 2, 2009. doi: 10.1158/0008-5472.CAN-08-4546 [Abstract] [Full Text] [PDF] Supplementary Data  

ROC1/RBX1 E3 Ubiquitin Ligase Silencing Suppresses Tumor Cell Growth via Sequential Induction of G₂-M Arrest, Apoptosis, and Senescence

Lijun Jia, Maria S. Soengas, and Yi Sun
Cancer Res 2009 69: 4974-4982. Published Online First June 9, 2009. doi: 10.1158/0008-5472.CAN-08-4671 [Abstract] [Full Text] [PDF] Supplementary Data  

N-myc Downstream Regulated Gene 1/Cap43 Suppresses Tumor Growth and Angiogenesis of Pancreatic Cancer through Attenuation of Inhibitor of B Kinase β Expression

Fumihito Hosoi, Hiroto Izumi, Akihiko Kawahara, Yuichi Murakami, Hisafumi Kinoshita, Masayoshi Kage, Kazuto Nishio, Kimitoshi Kohno, Michihiko Kuwano, and Mayumi Ono
Cancer Res 2009 69: 4983-4991. Published Online First June 2, 2009. doi: 10.1158/0008-5472.CAN-08-4882 [Abstract] [Full Text] [PDF] Supplementary Data  

Abrogating Drug Resistance in Malignant Peripheral Nerve Sheath Tumors by Disrupting Hyaluronan-CD44 Interactions with Small Hyaluronan Oligosaccharides

Mark G. Slomiany, Lu Dai, Paul A. Bomar, Thomas J. Knackstedt, D. Alex Kranc, Lauren Tolliver, Bernard L. Maria, and Bryan P. Toole
Cancer Res 2009 69: 4992-4998. Published Online First May 26, 2009. doi: 10.1158/0008-5472.CAN-09-0143 [Abstract] [Full Text] [PDF]  

PUMA Suppresses Intestinal Tumorigenesis in Mice

Wei Qiu, Eleanor B. Carson-Walter, Shih Fan Kuan, Lin Zhang, and Jian Yu
Cancer Res 2009 69: 4999-5006. Published Online First June 2, 2009. doi: 10.1158/0008-5472.CAN-09-0262 [Abstract] [Full Text] [PDF] Supplementary Data  

Extracellular Engagement of ₆ Integrin Inhibited Urokinase-Type Plasminogen Activator–Mediated Cleavage and Delayed Human Prostate Bone Metastasis

Michael O. Ports, Ray B. Nagle, Gerald D. Pond, and Anne E. Cress
Cancer Res 2009 69: 5007-5014. Published Online First June 2, 2009. doi: 10.1158/0008-5472.CAN-09-0354 [Abstract] [Full Text] [PDF]  

Notch Activation Induces Akt Signaling via an Autocrine Loop to Prevent Apoptosis in Breast Epithelial Cells

Olivier Meurette, Spyros Stylianou, Rebecca Rock, Giovanna M. Collu, Andrew P. Gilmore, and Keith Brennan
Cancer Res 2009 69: 5015-5022. Published Online First June 2, 2009. doi: 10.1158/0008-5472.CAN-08-3478 [Abstract] [Full Text] [PDF]  

Critical Role for Caspase-8 in Epidermal Growth Factor Signaling

Darren Finlay, Amy Howes, and Kristiina Vuori
Cancer Res 2009 69: 5023-5029. Published Online First May 26, 2009. doi: 10.1158/0008-5472.CAN-08-3731 [Abstract] [Full Text] [PDF]  

Loss of Retinal Cadherin Facilitates Mammary Tumor Progression and Metastasis

Georgia Agiostratidou, Maomi Li, Kimita Suyama, Ines Badano, Rinat Keren, Su Chung, Amy Anzovino, James Hulit, Binzhi Qian, Boumediene Bouzahzah, Eliseo Eugenin, Olivier Loudig, Greg R. Phillips, Joseph Locker, and Rachel B. Hazan
Cancer Res 2009 69: 5030-5038. Published Online First June 2, 2009. doi: 10.1158/0008-5472.CAN-08-4007 [Abstract] [Full Text] [PDF] Supplementary Data  

The Activated Notch1 Signal Pathway Is Associated with Gastric Cancer Progression through Cyclooxygenase-2

Tien-Shun Yeh, Chew-Wun Wu, Kai-Wen Hsu, Wan-Jung Liao, Min-Chieh Yang, Anna Fen-Yau Li, An-Ming Wang, Min-Liang Kuo, and Chin-Wen Chi
Cancer Res 2009 69: 5039-5048. Published Online First June 2, 2009. doi: 10.1158/0008-5472.CAN-08-4021 [Abstract] [Full Text] [PDF] Supplementary Data  

TOB1 Is Regulated by EGF-Dependent HER2 and EGFR Signaling, Is Highly Phosphorylated, and Indicates Poor Prognosis in Node-Negative Breast Cancer

Mike W. Helms, Dirk Kemming, Christopher H. Contag, Heike Pospisil, Kai Bartkowiak, Alice Wang, Sheng-Yung Chang, Horst Buerger, and Burkhard H. Brandt
Cancer Res 2009 69: 5049-5056. Published Online First June 2, 2009. doi: 10.1158/0008-5472.CAN-08-4154 [Abstract] [Full Text] [PDF]  

Akt1 and Akt2 Play Distinct Roles in the Initiation and Metastatic Phases of Mammary Tumor Progression

Rachelle L. Dillon, Richard Marcotte, Bryan T. Hennessy, James R. Woodgett, Gordon B. Mills, and William J. Muller
Cancer Res 2009 69: 5057-5064. Published Online First June 2, 2009. doi: 10.1158/0008-5472.CAN-08-4287 [Abstract] [Full Text] [PDF] Supplementary Data  

Epidemiology:

Genetic Variants on Chromosome 15q25 Associated with Lung Cancer Risk in Chinese Populations

Chen Wu, Zhibin Hu, Dianke Yu, Liming Huang, Guangfu Jin, Jie Liang, Huan Guo, Wen Tan, Mingfeng Zhang, Ji Qian, Daru Lu, Tangchun Wu, Dongxin Lin, and Hongbing Shen
Cancer Res 2009 69: 5065-5072. Published Online First June 2, 2009. doi: 10.1158/0008-5472.CAN-09-0081 [Abstract] [Full Text] [PDF] Supplementary Data  

Experimental Therapeutics, Molecular Targets, and Chemical Biology:

In vitro and In vivo Activity of Novel Small-Molecule Inhibitors Targeting the Pleckstrin Homology Domain of Protein Kinase B/AKT

Sylvestor A. Moses, M. Ahad Ali, Song Zuohe, Lei Du-Cuny, Li Li Zhou, Robert Lemos, Nathan Ihle, A. Geoffrey Skillman, Shuxing Zhang, Eugene A. Mash, Garth Powis, and Emmanuelle J. Meuillet
Cancer Res 2009 69: 5073-5081. Published Online First June 2, 2009. doi: 10.1158/0008-5472.CAN-08-3839 [Abstract] [Full Text] [PDF] Supplementary Data  

Targeting Angiogenesis via a c-Myc/Hypoxia-Inducible Factor-1–Dependent Pathway in Multiple Myeloma

Jing Zhang, Martin Sattler, Giovanni Tonon, Clemens Grabher, Samir Lababidi, Alexander Zimmerhackl, Marc S. Raab, Sonia Vallet, Yiming Zhou, Marie-Astrid Cartron, Teru Hideshima, Yu-Tzu Tai, Dharminder Chauhan, Kenneth C. Anderson, and Klaus Podar
Cancer Res 2009 69: 5082-5090. Published Online First June 9, 2009. doi: 10.1158/0008-5472.CAN-08-4603 [Abstract] [Full Text] [PDF] Supplementary Data  

Effects of Vandetanib on Lung Adenocarcinoma Cells Harboring Epidermal Growth Factor Receptor T790M Mutation In vivo

Eiki Ichihara, Kadoaki Ohashi, Nagio Takigawa, Masahiro Osawa, Atsuko Ogino, Mitsune Tanimoto, and Katsuyuki Kiura
Cancer Res 2009 69: 5091-5098. Published Online First June 2, 2009. doi: 10.1158/0008-5472.CAN-08-4204 [Abstract] [Full Text] [PDF]  

Human Schwannomas Express Activated Platelet-Derived Growth Factor Receptors and c-kit and Are Growth Inhibited by Gleevec (Imatinib Mesylate)

Joydeep Mukherjee, Deepak Kamnasaran, Anand Balasubramaniam, Ivan Radovanovic, Gelareh Zadeh, Tim-Rasmus Kiehl, and Abhijit Guha
Cancer Res 2009 69: 5099-5107. Published Online First June 9, 2009. doi: 10.1158/0008-5472.CAN-08-4475 [Abstract] [Full Text] [PDF] Supplementary Data  

Role of Cell Cycle in Epidermal Growth Factor Receptor Inhibitor-Mediated Radiosensitization

Aarif Ahsan, Susan M. Hiniker, Mary A. Davis, Theodore S. Lawrence, and Mukesh K. Nyati
Cancer Res 2009 69: 5108-5114. Published Online First June 9, 2009. doi: 10.1158/0008-5472.CAN-09-0466 [Abstract] [Full Text] [PDF] Supplementary Data  

Epithelial Phenotype Confers Resistance of Ovarian Cancer Cells to Oncolytic Adenoviruses

Robert Strauss, Pavel Sova, Ying Liu, Zong Yi Li, Sebastian Tuve, David Pritchard, Paul Brinkkoetter, Thomas Möller, Oliver Wildner, Sari Pesonen, Akseli Hemminki, Nicole Urban, Charles Drescher, and André Lieber
Cancer Res 2009 69: 5115-5125. Published Online First June 2, 2009. doi: 10.1158/0008-5472.CAN-09-0645 [Abstract] [Full Text] [PDF] Supplementary Data  

Targeting Tumor Endothelial Marker 8 in the Tumor Vasculature of Colorectal Carcinomas in Mice

Stephen Fernando and Bradley S. Fletcher
Cancer Res 2009 69: 5126-5132. doi: 10.1158/0008-5472.CAN-09-0725 [Abstract] [Full Text] [PDF]  

Direct Targeting of the Mucin 1 Oncoprotein Blocks Survival and Tumorigenicity of Human Breast Carcinoma Cells

Deepak Raina, Rehan Ahmad, Maya Datt Joshi, Li Yin, Zekui Wu, Takeshi Kawano, Baldev Vasir, David Avigan, Surender Kharbanda, and Donald Kufe
Cancer Res 2009 69: 5133-5141. Published Online First June 2, 2009. doi: 10.1158/0008-5472.CAN-09-0854 [Abstract] [Full Text] [PDF] Supplementary Data  

Immunology:

Inhibition of Transforming Growth Factor-β–Mediated Immunosuppression in Tumor-Draining Lymph Nodes Augments Antitumor Responses by Various Immunologic Cell Types

Takuya Fujita, Koji Teramoto, Yoshitomo Ozaki, Jun Hanaoka, Noriaki Tezuka, Yasushi Itoh, Tohru Asai, Shozo Fujino, Keiichi Kontani, and Kazumasa Ogasawara
Cancer Res 2009 69: 5142-5150. Published Online First June 2, 2009. doi: 10.1158/0008-5472.CAN-08-2499 [Abstract] [Full Text] [PDF] Supplementary Data  

Donor CD4 T Cells Are Critical in Allogeneic Stem Cell Transplantation against Murine Solid Tumor

Yoriyuki Kamiryo, Masatoshi Eto, Hisakata Yamada, Toshiki Yajima, Masahiko Harano, Ario Takeuchi, Katsunori Tatsugami, Masumitsu Hamaguchi, Seiji Naito, and Yasunobu Yoshikai
Cancer Res 2009 69: 5151-5158. Published Online First June 2, 2009. doi: 10.1158/0008-5472.CAN-08-2517 [Abstract] [Full Text] [PDF]  

Molecular Biology, Pathobiology, and Genetics:

Microalterations of Inherently Unstable Genomic Regions in Rat Mammary Carcinomas as Revealed by Long Oligonucleotide Array-Based Comparative Genomic Hybridization

Tatjana Adamovic, Donna McAllister, Victor Guryev, Xujing Wang, Jaime Wendt Andrae, Edwin Cuppen, Howard J. Jacob, and Sonia L. Sugg
Cancer Res 2009 69: 5159-5167. Published Online First June 9, 2009. doi: 10.1158/0008-5472.CAN-08-4038 [Abstract] [Full Text] [PDF]  

The mRNA-Destabilizing Protein Tristetraprolin Is Suppressed in Many Cancers, Altering Tumorigenic Phenotypes and Patient Prognosis

Sarah E. Brennan, Yuki Kuwano, Nadim Alkharouf, Perry J. Blackshear, Myriam Gorospe, and Gerald M. Wilson
Cancer Res 2009 69: 5168-5176. Published Online First June 2, 2009. doi: 10.1158/0008-5472.CAN-08-4238 [Abstract] [Full Text] [PDF] Supplementary Data  

Regulation of DNA Polymerase β by the LMP1 Oncoprotein of EBV through the Nuclear Factor-B Pathway

Nathalie Faumont, Christophe Le Clorennec, Pierre Teira, Gauthier Goormachtigh, Jean Coll, Yvan Canitrot, Christophe Cazaux, Jean-Sébastien Hoffmann, Pierre Brousset, Georges Delsol, Jean Feuillard, and Fabienne Meggetto
Cancer Res 2009 69: 5177-5185. Published Online First June 2, 2009. doi: 10.1158/0008-5472.CAN-08-2866 [Abstract] [Full Text] [PDF]  

Estrogen-Related Receptor Expression and Function Is Associated with the Transcriptional Coregulator AIB1 in Breast Carcinoma

Stefanie Heck, Joachim Rom, Verena Thewes, Natalia Becker, Beatrix Blume, Hans Peter Sinn, Ulrich Deuschle, Christof Sohn, Andreas Schneeweiss, and Peter Lichter
Cancer Res 2009 69: 5186-5193. Published Online First June 2, 2009. doi: 10.1158/0008-5472.CAN-08-3062 [Abstract] [Full Text] [PDF] Supplementary Data  

CMTM3, Located at the Critical Tumor Suppressor Locus 16q22.1, Is Silenced by CpG Methylation in Carcinomas and Inhibits Tumor Cell Growth through Inducing Apoptosis

Yu Wang, Jisheng Li, Yan Cui, Ting Li, Ka Man Ng, Hua Geng, Henan Li, Xing-sheng Shu, Hongyu Li, Wei Liu, Bing Luo, Qian Zhang, Tony Shu Kam Mok, Wei Zheng, Xiaoyan Qiu, Gopesh Srivastava, Jun Yu, Joseph J.Y. Sung, Anthony T.C. Chan, Dalong Ma, Qian Tao, and Wenling Han
Cancer Res 2009 69: 5194-5201. Published Online First June 9, 2009. doi: 10.1158/0008-5472.CAN-08-3694 [Abstract] [Full Text] [PDF] Supplementary Data  

Androgen Receptor Expression in Prostate Cancer Cells Is Suppressed by Activation of Epidermal Growth Factor Receptor and ErbB2

Changmeng Cai, David C. Portnoy, Hongyun Wang, Xinnong Jiang, Shaoyong Chen, and Steven P. Balk
Cancer Res 2009 69: 5202-5209. Published Online First June 2, 2009. doi: 10.1158/0008-5472.CAN-09-0026 [Abstract] [Full Text] [PDF]  

A Novel Type of p53 Pathway Dysfunction in Chronic Lymphocytic Leukemia Resulting from Two Interacting Single Nucleotide Polymorphisms within the p21 Gene

Gillian G. Johnson, Paul D. Sherrington, Anthony Carter, Ke Lin, Triantafillos Liloglou, John K. Field, and Andrew R. Pettitt
Cancer Res 2009 69: 5210-5217. Published Online First June 2, 2009. doi: 10.1158/0008-5472.CAN-09-0627 [Abstract] [Full Text] [PDF] Supplementary Data  

Mechanism of Regulation and Suppression of Melanoma Invasiveness by Novel Retinoic Acid Receptor- Target Gene Carbohydrate Sulfotransferase 10

Xiansi Zhao, Carole Graves, Sarah J. Ames, David E. Fisher, and Remco A. Spanjaard
Cancer Res 2009 69: 5218-5225. Published Online First May 26, 2009. doi: 10.1158/0008-5472.CAN-09-0705 [Abstract] [Full Text] [PDF] Supplementary Data  

Prevention:

Biological Significance of Prolactin in Gynecologic Cancers

Vera V. Levina, Brian Nolen, YunYun Su, Andrew K. Godwin, David Fishman, Jinsong Liu, Gil Mor, Larry G. Maxwell, Ronald B. Herberman, Miroslaw J. Szczepanski, Marta E. Szajnik, Elieser Gorelik, and Anna E. Lokshin
Cancer Res 2009 69: 5226-5233. Published Online First June 2, 2009. doi: 10.1158/0008-5472.CAN-08-4652 [Abstract] [Full Text] [PDF] Supplementary Data  

Systems Biology and Emerging Technologies:

Quantitative Assessment of the Complex Dynamics of G₁, S, and G₂-M Checkpoint Activities

Paolo Ubezio, Monica Lupi, Davide Branduardi, Paolo Cappella, Edoardo Cavallini, Valentina Colombo, Giada Matera, Claudia Natoli, Daniela Tomasoni, and Maurizio D'Incalci
Cancer Res 2009 69: 5234-5240. Published Online First June 9, 2009. doi: 10.1158/0008-5472.CAN-08-3911 [Abstract] [Full Text] [PDF] Supplementary Data  

Analysis of Gene Expression Profiles of Microdissected Cell Populations Indicates that Testicular Carcinoma In situ Is an Arrested Gonocyte

Si Brask Sonne, Kristian Almstrup, Marlene Dalgaard, Agnieszka Sierakowska Juncker, Daniel Edsgard, Ludmila Ruban, Neil J. Harrison, Christian Schwager, Amir Abdollahi, Peter E. Huber, Søren Brunak, Lise Mette Gjerdrum, Harry D. Moore, Peter W. Andrews, Niels E. Skakkebaek, Ewa Rajpert-De Meyts, and Henrik Leffers
Cancer Res 2009 69: 5241-5250. Published Online First June 2, 2009. doi: 10.1158/0008-5472.CAN-08-4554 [Abstract] [Full Text] [PDF] Supplementary Data  

Stepwise DNA Methylation Changes Are Linked to Escape from Defined Proliferation Barriers and Mammary Epithelial Cell Immortalization

Petr Novak, Taylor J. Jensen, James C. Garbe, Martha R. Stampfer, and Bernard W. Futscher
Cancer Res 2009 69: 5251-5258. Published Online First June 9, 2009. doi: 10.1158/0008-5472.CAN-08-4977 [Abstract] [Full Text] [PDF] Supplementary Data  

Tumor Microenvironment:

White Adipose Tissue Cells Are Recruited by Experimental Tumors and Promote Cancer Progression in Mouse Models

Yan Zhang, Alexes Daquinag, Dmitry O. Traktuev, Felipe Amaya-Manzanares, Paul J. Simmons, Keith L. March, Renata Pasqualini, Wadih Arap, and Mikhail G. Kolonin
Cancer Res 2009 69: 5259-5266. Published Online First June 2, 2009. doi: 10.1158/0008-5472.CAN-08-3444 [Abstract] [Full Text] [PDF] Supplementary Data  

Corrections:

Correction: Article on VDR Polymorphisms and Ovarian Cancer

Cancer Res 2009 69: 5267. Published Online First June 2, 2009. doi: 10.1158/0008-5472.CAN-69-12-COR1 [Full Text] [PDF]  

Correction: Article on DNA Copy Number Alterations in Ovarian Cancer

Cancer Res 2009 69: 5267. Published Online First June 2, 2009. doi: 10.1158/0008-5472.CAN-69-12-COR2 [Full Text] [PDF]  

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