AACR Centennial Series:

Advances in Radiotherapy and Implications for the Next Century: A Historical Perspective

Philip P. Connell and Samuel Hellman
Cancer Res 2009 69: 383-392. doi: 10.1158/0008-5472.CAN-07-6871 [Full Text] [PDF]  

Reviews:

MicroRNA Silencing in Primates: Towards Development of Novel Therapeutics

Andreas Petri, Morten Lindow, and Sakari Kauppinen
Cancer Res 2009 69: 393-395. doi: 10.1158/0008-5472.CAN-08-2749 [Abstract] [Full Text] [PDF]  

Modulation of G Protein Signaling Normalizes Tumor Vessels

Mitali Manzur, Juliana Hamzah, and Ruth Ganss
Cancer Res 2009 69: 396-399. doi: 10.1158/0008-5472.CAN-08-2842 [Abstract] [Full Text] [PDF]  

On the Role of Cell Signaling Models in Cancer Research

Alejandra C. Ventura, Trachette L. Jackson, and Sofia D. Merajver
Cancer Res 2009 69: 400-402. doi: 10.1158/0008-5472.CAN-08-4422 [Abstract] [Full Text] [PDF]  

Meeting Reports:

Advances and Challenges in Basic and Translational Research on Clusterin

Ioannis P. Trougakos, Julie Y. Djeu, Efstathios S. Gonos, and David A. Boothman
Cancer Res 2009 69: 403-406. doi: 10.1158/0008-5472.CAN-08-2912 [Full Text] [PDF] Supplementary Data  

Twentieth Annual Pezcoller Symposium: Molecular Biology of Cancer—20 Years of Progress Punctuated by the Pezcoller Symposia

Enrico Mihich
Cancer Res 2009 69: 407-410. doi: 10.1158/0008-5472.CAN-08-3155 [Full Text] [PDF]  

Priority Reports:

Host CXCR2-Dependent Regulation of Melanoma Growth, Angiogenesis, and Experimental Lung Metastasis

Seema Singh, Michelle Varney, and Rakesh K. Singh
Cancer Res 2009 69: 411-415. doi: 10.1158/0008-5472.CAN-08-3378 [Abstract] [Full Text] [PDF]  

Reversal of P-glycoprotein–Mediated Multidrug Resistance by the Murine Double Minute 2 Antagonist Nutlin-3

Martin Michaelis, Florian Rothweiler, Denise Klassert, Andreas von Deimling, Kristoffer Weber, Boris Fehse, Bernd Kammerer, Hans Wilhelm Doerr, and Jindrich Cinatl, Jr.
Cancer Res 2009 69: 416-421. doi: 10.1158/0008-5472.CAN-08-1856 [Abstract] [Full Text] [PDF] Supplementary Data  

Cell, Tumor, and Stem Cell Biology:

Pancreatic Cancer and Precursor Pancreatic Intraepithelial Neoplasia Lesions Are Devoid of Primary Cilia

E. Scott Seeley, Catherine Carrière, Tobias Goetze, Daniel S. Longnecker, and Murray Korc
Cancer Res 2009 69: 422-430. doi: 10.1158/0008-5472.CAN-08-1290 [Abstract] [Full Text] [PDF] Supplementary Data  

De novo Induction of Genetically Engineered Brain Tumors in Mice Using Plasmid DNA

Stephen M. Wiesner, Stacy A. Decker, Jon D. Larson, Katya Ericson, Colleen Forster, Jose L. Gallardo, Chunmei Long, Zachary L. Demorest, Edward A. Zamora, Walter C. Low, Karen SantaCruz, David A. Largaespada, and John R. Ohlfest
Cancer Res 2009 69: 431-439. doi: 10.1158/0008-5472.CAN-08-1800 [Abstract] [Full Text] [PDF] Supplementary Data  

p18^Ink4c and p53 Act as Tumor Suppressors in Cyclin D1–Driven Primitive Neuroectodermal Tumor

Raya Saab, Carlos Rodriguez-Galindo, Kelly Matmati, Jerold E. Rehg, Shannon H. Baumer, Joseph D. Khoury, Catherine Billups, Geoffrey Neale, Kathleen J. Helton, and Stephen X. Skapek
Cancer Res 2009 69: 440-448. doi: 10.1158/0008-5472.CAN-08-1892 [Abstract] [Full Text] [PDF] Supplementary Data  

Down-regulation of Rap1GAP via Promoter Hypermethylation Promotes Melanoma Cell Proliferation, Survival, and Migration

Hong Zheng, Ling Gao, Yunfeng Feng, Liya Yuan, Haibo Zhao, and Lynn A. Cornelius
Cancer Res 2009 69: 449-457. doi: 10.1158/0008-5472.CAN-08-2399 [Abstract] [Full Text] [PDF] Supplementary Data  

Tenascin-C Is a Novel RBPJ-Induced Target Gene for Notch Signaling in Gliomas

Balasubramanian Sivasankaran, Martin Degen, Anthony Ghaffari, Monika E. Hegi, Marie-France Hamou, Mihai-Constantin S. Ionescu, Christian Zweifel, Markus Tolnay, Morten Wasner, Susanne Mergenthaler, André R. Miserez, Robert Kiss, Maddalena M. Lino, Adrian Merlo, Ruth Chiquet-Ehrismann, and Jean-Louis Boulay
Cancer Res 2009 69: 458-465. doi: 10.1158/0008-5472.CAN-08-2610 [Abstract] [Full Text] [PDF]  

Mammary Epithelial-Specific Ablation of the Focal Adhesion Kinase Suppresses Mammary Tumorigenesis by Affecting Mammary Cancer Stem/Progenitor Cells

Ming Luo, Huaping Fan, Tamas Nagy, Huijun Wei, Chenran Wang, Suling Liu, Max S. Wicha, and Jun-Lin Guan
Cancer Res 2009 69: 466-474. doi: 10.1158/0008-5472.CAN-08-3078 [Abstract] [Full Text] [PDF] Supplementary Data  

Transforming Growth Factor β Induces Clustering of HER2 and Integrins by Activating Src-Focal Adhesion Kinase and Receptor Association to the Cytoskeleton

Shizhen Emily Wang, Bin Xiang, Roy Zent, Vito Quaranta, Ambra Pozzi, and Carlos L. Arteaga
Cancer Res 2009 69: 475-482. doi: 10.1158/0008-5472.CAN-08-2649 [Abstract] [Full Text] [PDF] Supplementary Data  

Overexpression of RhoA Induces Preneoplastic Transformation of Primary Mammary Epithelial Cells

Xiangshan Zhao, Lin Lu, Nidhi Pokhriyal, Hui Ma, Lei Duan, Simon Lin, Nadereh Jafari, Hamid Band, and Vimla Band
Cancer Res 2009 69: 483-491. doi: 10.1158/0008-5472.CAN-08-2907 [Abstract] [Full Text] [PDF] Supplementary Data  

Apoptosis Repressor with Caspase Recruitment Domain Contributes to Chemotherapy Resistance by Abolishing Mitochondrial Fission Mediated by Dynamin-Related Protein-1

Jian-Xun Wang, Qian Li, and Pei-Feng Li
Cancer Res 2009 69: 492-500. doi: 10.1158/0008-5472.CAN-08-2962 [Abstract] [Full Text] [PDF]  

Endocrinology:

Thyroid Hormone Receptor β1 Acts as a Potent Suppressor of Tumor Invasiveness and Metastasis

Olaia Martínez-Iglesias, Susana Garcia-Silva, Stephan P. Tenbaum, Javier Regadera, Fernando Larcher, Jesus M. Paramio, Bjorn Vennström, and Ana Aranda
Cancer Res 2009 69: 501-509. doi: 10.1158/0008-5472.CAN-08-2198 [Abstract] [Full Text] [PDF] Supplementary Data  

Experimental Therapeutics, Molecular Targets, and Chemical Biology:

Identification of Nuclear Export Inhibitors with Potent Anticancer Activity In vivo

Sarah C. Mutka, Wen Qing Yang, Steven D. Dong, Shannon L. Ward, Darren A. Craig, Pieter B.M.W.M. Timmermans, and Sumati Murli
Cancer Res 2009 69: 510-517. doi: 10.1158/0008-5472.CAN-08-0858 [Abstract] [Full Text] [PDF] Supplementary Data  

Morelloflavone, a Biflavonoid, Inhibits Tumor Angiogenesis by Targeting Rho GTPases and Extracellular Signal-Regulated Kinase Signaling Pathways

Xiufeng Pang, Tingfang Yi, Zhengfang Yi, Sung Gook Cho, Weijing Qu, Decha Pinkaew, Ken Fujise, and Mingyao Liu
Cancer Res 2009 69: 518-525. doi: 10.1158/0008-5472.CAN-08-2531 [Abstract] [Full Text] [PDF]  

Glycosaminoglycans as Potential Regulators of Osteoprotegerin Therapeutic Activity in Osteosarcoma

Francois Lamoureux, Gaëlle Picarda, Laure Garrigue-Antar, Marc Baud'huin, Valerie Trichet, André Vidal, Elisabeth Miot-Noirault, Bruno Pitard, Dominique Heymann, and Françoise Rédini
Cancer Res 2009 69: 526-536. doi: 10.1158/0008-5472.CAN-08-2648 [Abstract] [Full Text] [PDF]  

Noncationic Peptides Obtained From Azurin Preferentially Enter Cancer Cells

Brad N. Taylor, Rajeshwari R. Mehta, Tohru Yamada, Fatima Lekmine, Konstantin Christov, Ananda M. Chakrabarty, Albert Green, Laura Bratescu, Anne Shilkaitis, Craig W. Beattie, and Tapas K. Das Gupta
Cancer Res 2009 69: 537-546. doi: 10.1158/0008-5472.CAN-08-2932 [Abstract] [Full Text] [PDF]  

Targeting Ornithine Decarboxylase Impairs Development of MYCN-Amplified Neuroblastoma

Robert J. Rounbehler, Weimin Li, Mark A. Hall, Chunying Yang, Mohammad Fallahi, and John L. Cleveland
Cancer Res 2009 69: 547-553. doi: 10.1158/0008-5472.CAN-08-2968 [Abstract] [Full Text] [PDF] Supplementary Data  

Combined Transductional Untargeting/Retargeting and Transcriptional Restriction Enhances Adenovirus Gene Targeting and Therapy for Hepatic Colorectal Cancer Tumors

Hua-Jung Li, Maaike Everts, Masato Yamamoto, David T. Curiel, and Harvey R. Herschman
Cancer Res 2009 69: 554-564. doi: 10.1158/0008-5472.CAN-08-3209 [Abstract] [Full Text] [PDF] Supplementary Data  

Basal Subtype and MAPK/ERK Kinase (MEK)-Phosphoinositide 3-Kinase Feedback Signaling Determine Susceptibility of Breast Cancer Cells to MEK Inhibition

Olga K. Mirzoeva, Debopriya Das, Laura M. Heiser, Sanchita Bhattacharya, Doris Siwak, Rina Gendelman, Nora Bayani, Nicholas J. Wang, Richard M. Neve, Yinghui Guan, Zhi Hu, Zachary Knight, Heidi S. Feiler, Philippe Gascard, Bahram Parvin, Paul T. Spellman, Kevan M. Shokat, Andrew J. Wyrobek, Mina J. Bissell, Frank McCormick, Wen-Lin Kuo, Gordon B. Mills, Joe W. Gray, and W. Michael Korn
Cancer Res 2009 69: 565-572. doi: 10.1158/0008-5472.CAN-08-3389 [Abstract] [Full Text] [PDF] Supplementary Data  

-Secretase Inhibitors Abrogate Oxaliplatin-Induced Activation of the Notch-1 Signaling Pathway in Colon Cancer Cells Resulting in Enhanced Chemosensitivity

Raymond D. Meng, Christopher C. Shelton, Yue-Ming Li, Li-Xuan Qin, Daniel Notterman, Philip B. Paty, and Gary K. Schwartz
Cancer Res 2009 69: 573-582. doi: 10.1158/0008-5472.CAN-08-2088 [Abstract] [Full Text] [PDF] Supplementary Data  

Epigallocatechin-3-Gallate, a Histone Acetyltransferase Inhibitor, Inhibits EBV-Induced B Lymphocyte Transformation via Suppression of RelA Acetylation

Kyung-Chul Choi, Myung Gu Jung, Yoo-Hyun Lee, Joo Chun Yoon, Seung Hyun Kwon, Hee-Bum Kang, Mi-Jeong Kim, Jeong-Heon Cha, Young Jun Kim, Woo Jin Jun, Jae Myun Lee, and Ho-Geun Yoon
Cancer Res 2009 69: 583-592. doi: 10.1158/0008-5472.CAN-08-2442 [Abstract] [Full Text] [PDF] Supplementary Data  

C-1027, A Radiomimetic Enediyne Anticancer Drug, Preferentially Targets Hypoxic Cells

Terry A. Beerman, Loretta S. Gawron, Seulkih Shin, Ben Shen, and Mary M. McHugh
Cancer Res 2009 69: 593-598. doi: 10.1158/0008-5472.CAN-08-2753 [Abstract] [Full Text] [PDF]  

Immunology:

Quantitative DNA Methylation Analysis of FOXP3 as a New Method for Counting Regulatory T Cells in Peripheral Blood and Solid Tissue

Georg Wieczorek, Anne Asemissen, Fabian Model, Ivana Turbachova, Stefan Floess, Volker Liebenberg, Udo Baron, Diana Stauch, Katja Kotsch, Johann Pratschke, Alf Hamann, Christoph Loddenkemper, Harald Stein, Hans Dieter Volk, Ulrich Hoffmüller, Andreas Grützkau, Alexander Mustea, Jochen Huehn, Carmen Scheibenbogen, and Sven Olek
Cancer Res 2009 69: 599-608. doi: 10.1158/0008-5472.CAN-08-2361 [Abstract] [Full Text] [PDF]  

Potentiating Endogenous Antitumor Immunity to Prostate Cancer through Combination Immunotherapy with CTLA4 Blockade and GM-CSF

Lawrence Fong, Serena S. Kwek, Shaun O'Brien, Brian Kavanagh, Douglas G. McNeel, Vivian Weinberg, Amy M. Lin, Jonathan Rosenberg, Charles J. Ryan, Brian I. Rini, and Eric J. Small
Cancer Res 2009 69: 609-615. doi: 10.1158/0008-5472.CAN-08-3529 [Abstract] [Full Text] [PDF]  

Molecular Biology, Pathobiology, and Genetics:

Melanoma Antigen-11 Inhibits the Hypoxia-Inducible Factor Prolyl Hydroxylase 2 and Activates Hypoxic Response

Olga Aprelikova, Silvia Pandolfi, Sean Tackett, Mark Ferreira, Konstantin Salnikow, Yvona Ward, John I. Risinger, J. Carl Barrett, and John Niederhuber
Cancer Res 2009 69: 616-624. doi: 10.1158/0008-5472.CAN-08-0811 [Abstract] [Full Text] [PDF] Supplementary Data  

A Susceptibility Locus for Papillary Thyroid Carcinoma on Chromosome 8q24

Huiling He, Rebecca Nagy, Sandya Liyanarachchi, Hong Jiao, Wei Li, Saul Suster, Juha Kere, and Albert de la Chapelle
Cancer Res 2009 69: 625-631. doi: 10.1158/0008-5472.CAN-08-1071 [Abstract] [Full Text] [PDF] Supplementary Data  

Helicobacter pylori Cytotoxin-Associated Gene A Activates the Signal Transducer and Activator of Transcription 3 Pathway In vitro and In vivo

Dana M. Bronte-Tinkew, Mauricio Terebiznik, Aime Franco, Michelle Ang, Diane Ahn, Hitomi Mimuro, Chihiro Sasakawa, Mark J. Ropeleski, Richard M. Peek, Jr., and Nicola L. Jones
Cancer Res 2009 69: 632-639. doi: 10.1158/0008-5472.CAN-08-1191 [Abstract] [Full Text] [PDF] Supplementary Data  

Genome-Wide Linkage Analysis of TMPRSS2-ERG Fusion in Familial Prostate Cancer

Matthias D. Hofer, Rainer Kuefer, Christiane Maier, Kathleen Herkommer, Sven Perner, Francesca Demichelis, Thomas Paiss, Walter Vogel, Mark A. Rubin, and Josef Hoegel
Cancer Res 2009 69: 640-646. doi: 10.1158/0008-5472.CAN-08-2008 [Abstract] [Full Text] [PDF] Supplementary Data  

Chromosomal Signatures of a Subset of High-Grade Premalignant Cervical Lesions Closely Resemble Invasive Carcinomas

Saskia M. Wilting, Renske D.M. Steenbergen, Marianne Tijssen, Wessel N. van Wieringen, Theo J.M. Helmerhorst, Folkert J. van Kemenade, Maaike C.G. Bleeker, Mark A. van de Wiel, Beatriz Carvalho, Gerrit A. Meijer, Bauke Ylstra, Chris J.L.M. Meijer, and Peter J.F. Snijders
Cancer Res 2009 69: 647-655. doi: 10.1158/0008-5472.CAN-08-2478 [Abstract] [Full Text] [PDF]  

Protein Kinase C βII and PKC/: Collaborating Partners in Colon Cancer Promotion and Progression

Nicole R. Murray, Justin Weems, Ursula Braun, Michael Leitges, and Alan P. Fields
Cancer Res 2009 69: 656-662. doi: 10.1158/0008-5472.CAN-08-3001 [Abstract] [Full Text] [PDF]  

High Frequency of TP53 Mutation in BRCA1 and Sporadic Basal-like Carcinomas but not in BRCA1 Luminal Breast Tumors

Elodie Manié, Anne Vincent-Salomon, Jacqueline Lehmann-Che, Gaelle Pierron, Elisabeth Turpin, Mathilde Warcoin, Nadège Gruel, Ingrid Lebigot, Xavier Sastre-Garau, Rosette Lidereau, Audrey Remenieras, Jean Feunteun, Olivier Delattre, Hugues de Thé, Dominique Stoppa-Lyonnet, and Marc-Henri Stern
Cancer Res 2009 69: 663-671. doi: 10.1158/0008-5472.CAN-08-1560 [Abstract] [Full Text] [PDF] Supplementary Data  

Unlike Esophageal Squamous Cells, Barrett's Epithelial Cells Resist Apoptosis by Activating the Nuclear Factor-B Pathway

Kathy Hormi-Carver, Xi Zhang, Hui Ying Zhang, Robert H. Whitehead, Lance S. Terada, Stuart J. Spechler, and Rhonda F. Souza
Cancer Res 2009 69: 672-677. doi: 10.1158/0008-5472.CAN-08-3703 [Abstract] [Full Text] [PDF]  

Tgfbr1 Haploinsufficiency Is a Potent Modifier of Colorectal Cancer Development

Qinghua Zeng, Sharbani Phukan, Yanfei Xu, Maureen Sadim, Diana S. Rosman, Michael Pennison, Jie Liao, Guang-Yu Yang, Chiang-Ching Huang, Laura Valle, Antonio Di Cristofano, Albert de la Chapelle, and Boris Pasche
Cancer Res 2009 69: 678-686. doi: 10.1158/0008-5472.CAN-08-3980 [Abstract] [Full Text] [PDF] Supplementary Data  

Prevention:

Inhibition of Peroxisome Proliferator-Activated Receptor Increases Estrogen Receptor–Dependent Tumor Specification

Yuzhi Yin, Hongyan Yuan, Xiao Zeng, Levy Kopelovich, and Robert I. Glazer
Cancer Res 2009 69: 687-694. doi: 10.1158/0008-5472.CAN-08-2446 [Abstract] [Full Text] [PDF] Supplementary Data  

Pretreatment with Statin Attenuates the Cardiotoxicity of Doxorubicin in Mice

Alexander Riad, Sandra Bien, Dirk Westermann, Peter M. Becher, Komal Loya, Ulf Landmesser, Heyo K. Kroemer, Heinz P. Schultheiss, and Carsten Tschöpe
Cancer Res 2009 69: 695-699. doi: 10.1158/0008-5472.CAN-08-3076 [Abstract] [Full Text] [PDF]  

Arginine Deiminase as a Novel Therapy for Prostate Cancer Induces Autophagy and Caspase-Independent Apoptosis

Randie H. Kim, Jodi M. Coates, Tawnya L. Bowles, Gregory P. McNerney, Julie Sutcliffe, Jae U. Jung, Regina Gandour-Edwards, Frank Y.S. Chuang, Richard J. Bold, and Hsing-Jien Kung
Cancer Res 2009 69: 700-708. doi: 10.1158/0008-5472.CAN-08-3157 [Abstract] [Full Text] [PDF]  

Systems Biology and Emerging Technologies:

Genome-Wide Promoter Analysis of the SOX4 Transcriptional Network in Prostate Cancer Cells

Christopher D. Scharer, Colleen D. McCabe, Mohamed Ali-Seyed, Michael F. Berger, Martha L. Bulyk, and Carlos S. Moreno
Cancer Res 2009 69: 709-717. doi: 10.1158/0008-5472.CAN-08-3415 [Abstract] [Full Text] [PDF] Supplementary Data  

Letters to the Editor:

Comment re: Nitrite Activates Estrogen Receptor-

Eddie Weitzberg, Filip Larsen, and Jon O. Lundberg
Cancer Res 2009 69: 718. doi: 10.1158/0008-5472.CAN-08-2094 [Full Text] [PDF]  

Comment re: Nitrite Activates Estrogen Receptor-

Mary Beth Martin and David Veselik
Cancer Res 2009 69: 718. doi: 10.1158/0008-5472.CAN-08-3576 [Full Text] [PDF]  

Comment re: Preclinical Model of Spontaneous Melanoma Metastasis

Robert M. Hoffman
Cancer Res 2009 69: 719. doi: 10.1158/0008-5472.CAN-08-3248 [Full Text] [PDF]  

Comment re: Preclinical Model of Spontaneous Melanoma Metastasis

William Cruz-Munoz and Robert S. Kerbel
Cancer Res 2009 69: 720. doi: 10.1158/0008-5472.CAN-08-4138 [Full Text] [PDF]  

Correction:

Correction: Tumor-Stroma Interactions in the Prostate

Cancer Res 2009 69: 721. doi: 10.1158/0008-5472.CAN-69-2-COR [Full Text] [PDF]  

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