AACR Centennial Series:

Landmarks in the History of Cancer Epidemiology

Peter Greenwald and Barbara K. Dunn
Cancer Res 2009 69: 2151-2162. Published Online First March 10, 2009. doi: 10.1158/0008-5472.CAN-09-0416 [Abstract] [Full Text] [PDF]  

Reviews:

Mitochondrial Uncoupling and the Warburg Effect: Molecular Basis for the Reprogramming of Cancer Cell Metabolism

Ismael Samudio, Michael Fiegl, and Michael Andreeff
Cancer Res 2009 69: 2163-2166. Published Online First March 3, 2009. doi: 10.1158/0008-5472.CAN-08-3722 [Abstract] [Full Text] [PDF]  

A Role for CXCR2 in Senescence, but What about in Cancer?

Juan C. Acosta and Jesús Gil
Cancer Res 2009 69: 2167-2170. Published Online First March 10, 2009. doi: 10.1158/0008-5472.CAN-08-3772 [Abstract] [Full Text] [PDF]  

Perspectives in Cancer Research:

Rethinking "Cancer as a Dynamic Developmental Disorder" a Quarter Century Later

Harry Rubin
Cancer Res 2009 69: 2171-2175. Published Online First March 3, 2009. doi: 10.1158/0008-5472.CAN-08-4213 [Abstract] [Full Text] [PDF]  

Priority Reports:

Association of a Germ-Line Copy Number Variation at 2p24.3 and Risk for Aggressive Prostate Cancer

Wennuan Liu, Jishan Sun, Ge Li, Yi Zhu, Scott Zhang, Seong-Tae Kim, Jielin Sun, Fredrik Wiklund, Kathleen Wiley, Sarah D. Isaacs, Pär Stattin, Jianfeng Xu, David Duggan, John D. Carpten, William B. Isaacs, Henrik Grönberg, S. Lilly Zheng, and Bao-Li Chang
Cancer Res 2009 69: 2176-2179. Published Online First March 3, 2009. doi: 10.1158/0008-5472.CAN-08-3151 [Abstract] [Full Text] [PDF] Supplementary Data  

Epigenetic Regulation of c-ROS Receptor Tyrosine Kinase Expression in Malignant Gliomas

Hyun Jung Jun, Steve Woolfenden, Shanie Coven, Keara Lane, Roderick Bronson, David Housman, and Alan Charest
Cancer Res 2009 69: 2180-2184. Published Online First March 10, 2009. doi: 10.1158/0008-5472.CAN-08-3351 [Abstract] [Full Text] [PDF] Supplementary Data  

Critical Role of Smad2 in Tumor Suppression and Transforming Growth Factor-β–Induced Apoptosis of Prostate Epithelial Cells

Jiayi Yang, Reema Wahdan-Alaswad, and David Danielpour
Cancer Res 2009 69: 2185-2190. Published Online First March 10, 2009. doi: 10.1158/0008-5472.CAN-08-3961 [Abstract] [Full Text] [PDF] Supplementary Data  

Trastuzumab-Induced HER Reprogramming in "Resistant" Breast Carcinoma Cells

Murli Narayan, Jason A. Wilken, Lyndsay N. Harris, Andre T. Baron, Kimberly D. Kimbler, and Nita J. Maihle
Cancer Res 2009 69: 2191-2194. Published Online First March 10, 2009. doi: 10.1158/0008-5472.CAN-08-1056 [Abstract] [Full Text] [PDF]  

microRNA-205 Regulates HER3 in Human Breast Cancer

Marilena V. Iorio, Patrizia Casalini, Claudia Piovan, Gianpiero Di Leva, Andrea Merlo, Tiziana Triulzi, Sylvie Ménard, Carlo M. Croce, and Elda Tagliabue
Cancer Res 2009 69: 2195-2200. Published Online First March 10, 2009. doi: 10.1158/0008-5472.CAN-08-2920 [Abstract] [Full Text] [PDF] Supplementary Data  

Cell, Tumor, and Stem Cell Biology:

ADP-Ribosylation Factor 6 Regulates Tumorigenic and Invasive Properties In vivo

Vandhana Muralidharan-Chari, Holly Hoover, James Clancy, Jill Schweitzer, Mark A. Suckow, Valerie Schroeder, Francis J. Castellino, Jeffrey S. Schorey, and Crislyn D'Souza-Schorey
Cancer Res 2009 69: 2201-2209. Published Online First March 10, 2009. doi: 10.1158/0008-5472.CAN-08-1301 [Abstract] [Full Text] [PDF] Supplementary Data  

Heterogeneous Nuclear Ribonucleoprotein K Is a Novel Regulator of Androgen Receptor Translation

Nishit K. Mukhopadhyay, Jayoung Kim, Bekir Cinar, Aruna Ramachandran, Martin H. Hager, Dolores Di Vizio, Rosalyn M. Adam, Mark A. Rubin, Pradip Raychaudhuri, Arrigo De Benedetti, and Michael R. Freeman
Cancer Res 2009 69: 2210-2218. Published Online First March 3, 2009. doi: 10.1158/0008-5472.CAN-08-2308 [Abstract] [Full Text] [PDF] Supplementary Data  

TWIST-1 Is Overexpressed in Neoplastic Choroid Plexus Epithelial Cells and Promotes Proliferation and Invasion

Martin Hasselblatt, Sonja Mertsch, Björn Koos, Barbara Riesmeier, Heike Stegemann, Astrid Jeibmann, Manuel Tomm, Nicole Schmitz, Brigitte Wrede, Johannes E. Wolff, Wei Zheng, and Werner Paulus
Cancer Res 2009 69: 2219-2223. Published Online First March 10, 2009. doi: 10.1158/0008-5472.CAN-08-3176 [Abstract] [Full Text] [PDF] Supplementary Data  

Rnd3 Regulation of the Actin Cytoskeleton Promotes Melanoma Migration and Invasive Outgrowth in Three Dimensions

R. Matthew Klein and Andrew E. Aplin
Cancer Res 2009 69: 2224-2233. Published Online First February 24, 2009. doi: 10.1158/0008-5472.CAN-08-3201 [Abstract] [Full Text] [PDF] Supplementary Data  

Coordinated Expression of Stathmin Family Members by Far Upstream Sequence Element-Binding Protein-1 Increases Motility in Non–Small Cell Lung Cancer

Stephan Singer, Mona Malz, Esther Herpel, Arne Warth, Michaela Bissinger, Martina Keith, Thomas Muley, Michael Meister, Hans Hoffmann, Roland Penzel, Georg Gdynia, Volker Ehemann, Philipp Albert Schnabel, Ruprecht Kuner, Peter Huber, Peter Schirmacher, and Kai Breuhahn
Cancer Res 2009 69: 2234-2243. Published Online First March 3, 2009. doi: 10.1158/0008-5472.CAN-08-3338 [Abstract] [Full Text] [PDF] Supplementary Data  

Fibroblast Growth Factor Receptor 1–Transformed Mammary Epithelial Cells Are Dependent on RSK Activity for Growth and Survival

Wa Xian, Leontios Pappas, Darshan Pandya, Laura M. Selfors, Patrick W. Derksen, Michiel de Bruin, Nathanael S. Gray, Jos Jonkers, Jeffrey M. Rosen, and Joan S. Brugge
Cancer Res 2009 69: 2244-2251. Published Online First March 3, 2009. doi: 10.1158/0008-5472.CAN-08-3398 [Abstract] [Full Text] [PDF] Supplementary Data  

FOXP3 Up-regulates p21 Expression by Site-Specific Inhibition of Histone Deacetylase 2/Histone Deacetylase 4 Association to the Locus

Runhua Liu, Lizhong Wang, Guoyun Chen, Hiroto Katoh, Chong Chen, Yang Liu, and Pan Zheng
Cancer Res 2009 69: 2252-2259. Published Online First March 10, 2009. doi: 10.1158/0008-5472.CAN-08-3717 [Abstract] [Full Text] [PDF] Supplementary Data  

Bicarbonate Increases Tumor pH and Inhibits Spontaneous Metastases

Ian F. Robey, Brenda K. Baggett, Nathaniel D. Kirkpatrick, Denise J. Roe, Julie Dosescu, Bonnie F. Sloane, Arig Ibrahim Hashim, David L. Morse, Natarajan Raghunand, Robert A. Gatenby, and Robert J. Gillies
Cancer Res 2009 69: 2260-2268. Published Online First March 10, 2009. doi: 10.1158/0008-5472.CAN-07-5575 [Abstract] [Full Text] [PDF] Supplementary Data  

Strong Smooth Muscle Differentiation Is Dependent on Myocardin Gene Amplification in Most Human Retroperitoneal Leiomyosarcomas

Gaëlle Pérot, Josette Derré, Jean-Michel Coindre, Franck Tirode, Carlo Lucchesi, Odette Mariani, Laure Gibault, Louis Guillou, Philippe Terrier, and Alain Aurias
Cancer Res 2009 69: 2269-2278. Published Online First March 10, 2009. doi: 10.1158/0008-5472.CAN-08-1443 [Abstract] [Full Text] [PDF] Supplementary Data  

Quantitative Phosphoproteomics Reveals a Cluster of Tyrosine Kinases That Mediates Src Invasive Activity in Advanced Colon Carcinoma Cells

Cédric Leroy, Camille Fialin, Audrey Sirvent, Valérie Simon, Serge Urbach, Joël Poncet, Bruno Robert, Patrick Jouin, and Serge Roche
Cancer Res 2009 69: 2279-2286. Published Online First March 10, 2009. doi: 10.1158/0008-5472.CAN-08-2354 [Abstract] [Full Text] [PDF] Supplementary Data  

miR-205 Exerts Tumor-Suppressive Functions in Human Prostate through Down-regulation of Protein Kinase C

Paolo Gandellini, Marco Folini, Nicole Longoni, Marzia Pennati, Mara Binda, Maurizio Colecchia, Roberto Salvioni, Rosanna Supino, Roberta Moretti, Patrizia Limonta, Riccardo Valdagni, Maria Grazia Daidone, and Nadia Zaffaroni
Cancer Res 2009 69: 2287-2295. Published Online First February 24, 2009. doi: 10.1158/0008-5472.CAN-08-2894 [Abstract] [Full Text] [PDF] Supplementary Data  

Activation of Meiosis-Specific Genes Is Associated with Depolyploidization of Human Tumor Cells following Radiation-Induced Mitotic Catastrophe

Fiorenza Ianzini, Elizabeth A. Kosmacek, Elke S. Nelson, Eleonora Napoli, Jekaterina Erenpreisa, Martins Kalejs, and Michael A. Mackey
Cancer Res 2009 69: 2296-2304. Published Online First March 3, 2009. doi: 10.1158/0008-5472.CAN-08-3364 [Abstract] [Full Text] [PDF] Supplementary Data  

A Novel Androgen Receptor Splice Variant Is Up-regulated during Prostate Cancer Progression and Promotes Androgen Depletion–Resistant Growth

Zhiyong Guo, Xi Yang, Feng Sun, Richeng Jiang, Douglas E. Linn, Hege Chen, Hegang Chen, Xiangtian Kong, Jonathan Melamed, Clifford G. Tepper, Hsing-Jien Kung, Angela M.H. Brodie, Joanne Edwards, and Yun Qiu
Cancer Res 2009 69: 2305-2313. Published Online First February 24, 2009. doi: 10.1158/0008-5472.CAN-08-3795 [Abstract] [Full Text] [PDF] Supplementary Data  

Aurora A Regulates Prometaphase Progression by Inhibiting the Ability of RASSF1A to Suppress APC-Cdc20 Activity

Su Jung Song, Min Sup Song, Soon Jung Kim, So Yeon Kim, Seung Hae Kwon, Jhin Gook Kim, Diego F. Calvisi, Dongmin Kang, and Dae-Sik Lim
Cancer Res 2009 69: 2314-2323. Published Online First March 10, 2009. doi: 10.1158/0008-5472.CAN-08-3984 [Abstract] [Full Text] [PDF] Supplementary Data  

E2F1 Induces Tumor Cell Survival via Nuclear Factor-B–Dependent Induction of EGR1 Transcription in Prostate Cancer Cells

Chaogu Zheng, Zijia Ren, Hetian Wang, Weici Zhang, Dhananjaya V. Kalvakolanu, Zhigang Tian, and Weihua Xiao
Cancer Res 2009 69: 2324-2331. Published Online First March 10, 2009. doi: 10.1158/0008-5472.CAN-08-4113 [Abstract] [Full Text] [PDF] Supplementary Data  

Endocrinology:

Androgen-Stimulated UDP-Glucose Dehydrogenase Expression Limits Prostate Androgen Availability without Impacting Hyaluronan Levels

Qin Wei, Robert Galbenus, Ashraf Raza, Ronald L. Cerny, and Melanie A. Simpson
Cancer Res 2009 69: 2332-2339. Published Online First February 24, 2009. doi: 10.1158/0008-5472.CAN-08-3083 [Abstract] [Full Text] [PDF] Supplementary Data  

Epidemiology:

CYP1A1/2 Haplotypes and Lung Cancer and Assessment of Confounding by Population Stratification

Melinda C. Aldrich, Steve Selvin, Helen M. Hansen, Lisa F. Barcellos, Margaret R. Wrensch, Jennette D. Sison, Karl T. Kelsey, Patricia A. Buffler, Charles P. Quesenberry, Jr., Michael F. Seldin, and John K. Wiencke
Cancer Res 2009 69: 2340-2348. Published Online First March 10, 2009. doi: 10.1158/0008-5472.CAN-08-2576 [Abstract] [Full Text] [PDF] Supplementary Data  

Single Nucleotide Polymorphisms in the TP53 Region and Susceptibility to Invasive Epithelial Ovarian Cancer

Joellen M. Schildkraut, Ellen L. Goode, Merlise A. Clyde, Edwin S. Iversen, Patricia G. Moorman, Andrew Berchuck, Jeffrey R. Marks, Jolanta Lissowska, Louise Brinton, Beata Peplonska, Julie M. Cunningham, Robert A. Vierkant, David N. Rider, Georgia Chenevix-Trench, Penelope M. Webb, Jonathan Beesley, Xiaoqing Chen, Catherine Phelan, Rebecca Sutphen, Thomas A. Sellers, Leigh Pearce, Anna H. Wu, David Van Den Berg, David Conti, Christopher K. Elund, Rebecca Anderson, Marc T. Goodman, Galina Lurie, Michael E. Carney, Pamela J. Thompson, Simon A. Gayther, Susan J. Ramus, Ian Jacobs, Susanne Krüger Kjaer, Estrid Hogdall, Jan Blaakaer, Claus Hogdall, Douglas F. Easton, Honglin Song, Paul D.P. Pharoah, Alice S. Whittemore, Valerie McGuire, Lydia Quaye, Hoda Anton-Culver, Argyrios Ziogas, Kathryn L. Terry, Daniel W. Cramer, Susan E. Hankinson, Shelley S. Tworoger, Brian Calingaert, Stephen Chanock, Mark Sherman, Montserrat Garcia-Closas, Australian Cancer Study (Ovarian Cancer) Australian Ovarian Cancer Study Group
Cancer Res 2009 69: 2349-2357. Published Online First March 10, 2009. doi: 10.1158/0008-5472.CAN-08-2902 [Abstract] [Full Text] [PDF] Supplementary Data  

Experimental Therapeutics, Molecular Targets, and Chemical Biology:

Antibody-Drug Conjugates for the Treatment of Non–Hodgkin's Lymphoma: Target and Linker-Drug Selection

Andrew G. Polson, Jill Calemine-Fenaux, Pamela Chan, Wesley Chang, Erin Christensen, Suzanna Clark, Frederic J. de Sauvage, Dan Eaton, Kristi Elkins, J. Michael Elliott, Gretchen Frantz, Reina N. Fuji, Alane Gray, Kristin Harden, Gladys S. Ingle, Noelyn M. Kljavin, Hartmut Koeppen, Christopher Nelson, Saileta Prabhu, Helga Raab, Sarajane Ross, Jean-Philippe Stephan, Suzie J. Scales, Susan D. Spencer, Richard Vandlen, Bernd Wranik, Shang-Fan Yu, Bing Zheng, and Allen Ebens
Cancer Res 2009 69: 2358-2364. Published Online First March 3, 2009. doi: 10.1158/0008-5472.CAN-08-2250 [Abstract] [Full Text] [PDF] Supplementary Data  

Inhibition of Constitutively Activated Nuclear Factor-B Induces Reactive Oxygen Species- and Iron-Dependent Cell Death in Cutaneous T-Cell Lymphoma

Michael K. Kiessling, Claus D. Klemke, Marcin M. Kaminski, Ioanna E. Galani, Peter H. Krammer, and Karsten Gülow
Cancer Res 2009 69: 2365-2374. Published Online First March 3, 2009. doi: 10.1158/0008-5472.CAN-08-3221 [Abstract] [Full Text] [PDF] Supplementary Data  

Mitochondrial Dysfunction and Reactive Oxygen Species Imbalance Promote Breast Cancer Cell Motility through a CXCL14-Mediated Mechanism

Helene Pelicano, Weiqin Lu, Yan Zhou, Wan Zhang, Zhao Chen, Yumin Hu, and Peng Huang
Cancer Res 2009 69: 2375-2383. Published Online First March 10, 2009. doi: 10.1158/0008-5472.CAN-08-3359 [Abstract] [Full Text] [PDF] Supplementary Data  

Equally Potent Inhibition of c-Src and Abl by Compounds that Recognize Inactive Kinase Conformations

Markus A. Seeliger, Pratistha Ranjitkar, Corynn Kasap, Yibing Shan, David E. Shaw, Neil P. Shah, John Kuriyan, and Dustin J. Maly
Cancer Res 2009 69: 2384-2392. Published Online First March 10, 2009. doi: 10.1158/0008-5472.CAN-08-3953 [Abstract] [Full Text] [PDF] Supplementary Data  

Immune Effector Cells Produce Lethal DNA Damage in Cells Treated with a Thiopurine

Ilse Daehn and Peter Karran
Cancer Res 2009 69: 2393-2399. Published Online First February 24, 2009. doi: 10.1158/0008-5472.CAN-08-4264 [Abstract] [Full Text] [PDF]  

Acquisition of Epithelial-Mesenchymal Transition Phenotype of Gemcitabine-Resistant Pancreatic Cancer Cells Is Linked with Activation of the Notch Signaling Pathway

Zhiwei Wang, Yiwei Li, Dejuan Kong, Sanjeev Banerjee, Aamir Ahmad, Asfar Sohail Azmi, Shadan Ali, James L. Abbruzzese, Gary E. Gallick, and Fazlul H. Sarkar
Cancer Res 2009 69: 2400-2407. Published Online First March 10, 2009. doi: 10.1158/0008-5472.CAN-08-4312 [Abstract] [Full Text] [PDF]  

Biodistributions, Myelosuppression, and Toxicities in Mice Treated with an Anti-CD45 Antibody Labeled with the -Emitting Radionuclides Bismuth-213 or Astatine-211

Hirohisa Nakamae, D. Scott Wilbur, Donald K. Hamlin, Monica S. Thakar, Erlinda B. Santos, Darrell R. Fisher, Aimee L. Kenoyer, John M. Pagel, Oliver W. Press, Rainer Storb, and Brenda M. Sandmaier
Cancer Res 2009 69: 2408-2415. Published Online First February 24, 2009. doi: 10.1158/0008-5472.CAN-08-4363 [Abstract] [Full Text] [PDF] Supplementary Data  

4-Hydroxyestradiol Induces Anchorage-Independent Growth of Human Mammary Epithelial Cells via Activation of IB Kinase: Potential Role of Reactive Oxygen Species

Sin-Aye Park, Hye-Kyung Na, Eun-Hee Kim, Young-Nam Cha, and Young-Joon Surh
Cancer Res 2009 69: 2416-2424. Published Online First March 10, 2009. doi: 10.1158/0008-5472.CAN-08-2177 [Abstract] [Full Text] [PDF]  

Small Molecule XIAP Inhibitors Enhance TRAIL-Induced Apoptosis and Antitumor Activity in Preclinical Models of Pancreatic Carcinoma

Meike Vogler, Henning Walczak, Dominic Stadel, Tobias L. Haas, Felicitas Genze, Marjana Jovanovic, Umesh Bhanot, Cornelia Hasel, Peter Möller, Jürgen E. Gschwend, Thomas Simmet, Klaus-Michael Debatin, and Simone Fulda
Cancer Res 2009 69: 2425-2434. Published Online First March 3, 2009. doi: 10.1158/0008-5472.CAN-08-2436 [Abstract] [Full Text] [PDF] Supplementary Data  

Engineered Knottin Peptides: A New Class of Agents for Imaging Integrin Expression in Living Subjects

Richard H. Kimura, Zhen Cheng, Sanjiv Sam Gambhir, and Jennifer R. Cochran
Cancer Res 2009 69: 2435-2442. Published Online First March 10, 2009. doi: 10.1158/0008-5472.CAN-08-2495 [Abstract] [Full Text] [PDF] Supplementary Data  

Insulin Receptor Isoform A and Insulin-like Growth Factor II as Additional Treatment Targets in Human Osteosarcoma

Sofia Avnet, Laura Sciacca, Manuela Salerno, Giovanni Gancitano, Maria Francesca Cassarino, Alessandra Longhi, Mahvash Zakikhani, Joan M. Carboni, Marco Gottardis, Armando Giunti, Michael Pollak, Riccardo Vigneri, and Nicola Baldini
Cancer Res 2009 69: 2443-2452. Published Online First March 3, 2009. doi: 10.1158/0008-5472.CAN-08-2645 [Abstract] [Full Text] [PDF]  

Silencing of Elongation Factor-2 Kinase Potentiates the Effect of 2-Deoxy-D-Glucose against Human Glioma Cells through Blunting of Autophagy

Hao Wu, Hua Zhu, David X. Liu, Ting-Kuang Niu, Xingcong Ren, Rajesh Patel, William N. Hait, and Jin-Ming Yang
Cancer Res 2009 69: 2453-2460. Published Online First February 24, 2009. doi: 10.1158/0008-5472.CAN-08-2872 [Abstract] [Full Text] [PDF]  

Cetuximab Attenuates Metastasis and u-PAR Expression in Non–Small Cell Lung Cancer: u-PAR and E-Cadherin are Novel Biomarkers of Cetuximab Sensitivity

Dessislava A. Nikolova, Irfan A. Asangani, Laura D. Nelson, Dennis P.M. Hughes, Doris R. Siwak, Gordon B. Mills, Andrea Harms, Erika Buchholz, Lothar R. Pilz, Christian Manegold, and Heike Allgayer
Cancer Res 2009 69: 2461-2470. Published Online First March 10, 2009. doi: 10.1158/0008-5472.CAN-08-3236 [Abstract] [Full Text] [PDF] Supplementary Data  

miR-34b Targets Cyclic AMP–Responsive Element Binding Protein in Acute Myeloid Leukemia

Martina Pigazzi, Elena Manara, Emma Baron, and Giuseppe Basso
Cancer Res 2009 69: 2471-2478. Published Online First March 3, 2009. doi: 10.1158/0008-5472.CAN-08-3404 [Abstract] [Full Text] [PDF] Supplementary Data  

Molecular Dosimetry of 1,2,3,4-Diepoxybutane–Induced DNA-DNA Cross-Links in B6C3F1 Mice and F344 Rats Exposed to 1,3-Butadiene by Inhalation

Melissa Goggin, James A. Swenberg, Vernon E. Walker, and Natalia Tretyakova
Cancer Res 2009 69: 2479-2486. Published Online First March 10, 2009. doi: 10.1158/0008-5472.CAN-08-4152 [Abstract] [Full Text] [PDF] Supplementary Data  

Immunology:

Recognition of Live Phosphatidylserine-Labeled Tumor Cells by Dendritic Cells: A Novel Approach to Immunotherapy of Skin Cancer

Michael R. Shurin, Alla I. Potapovich, Yulia Y. Tyurina, Irina L. Tourkova, Galina V. Shurin, and Valerian E. Kagan
Cancer Res 2009 69: 2487-2496. Published Online First March 10, 2009. doi: 10.1158/0008-5472.CAN-08-2611 [Abstract] [Full Text] [PDF]  

Toll-like Receptor 9 Activation of Signal Transducer and Activator of Transcription 3 Constrains Its Agonist-Based Immunotherapy

Marcin Kortylewski, Maciej Kujawski, Andreas Herrmann, Chunmei Yang, Lin Wang, Yong Liu, Rosalba Salcedo, and Hua Yu
Cancer Res 2009 69: 2497-2505. Published Online First March 3, 2009. doi: 10.1158/0008-5472.CAN-08-3031 [Abstract] [Full Text] [PDF] Supplementary Data  

Sunitinib Inhibition of Stat3 Induces Renal Cell Carcinoma Tumor Cell Apoptosis and Reduces Immunosuppressive Cells

Hong Xin, Chunyan Zhang, Andreas Herrmann, Yan Du, Robert Figlin, and Hua Yu
Cancer Res 2009 69: 2506-2513. Published Online First February 24, 2009. doi: 10.1158/0008-5472.CAN-08-4323 [Abstract] [Full Text] [PDF] Supplementary Data  

The Novel Role of Tyrosine Kinase Inhibitor in the Reversal of Immune Suppression and Modulation of Tumor Microenvironment for Immune-Based Cancer Therapies

Junko Ozao-Choy, Ge Ma, Johnny Kao, George X. Wang, Marcia Meseck, Max Sung, Myron Schwartz, Celia M. Divino, Ping-Ying Pan, and Shu-Hsia Chen
Cancer Res 2009 69: 2514-2522. Published Online First March 10, 2009. doi: 10.1158/0008-5472.CAN-08-4709 [Abstract] [Full Text] [PDF]  

Interleukin-27 Activates Natural Killer Cells and Suppresses NK-Resistant Head and Neck Squamous Cell Carcinoma through Inducing Antibody-Dependent Cellular Cytotoxicity

Masahiro Matsui, Tsunao Kishida, Hiroshi Nakano, Koichiro Yoshimoto, Masaharu Shin-Ya, Taketoshi Shimada, Shigeru Nakai, Jiro Imanishi, Takayuki Yoshimoto, Yasuo Hisa, and Osam Mazda
Cancer Res 2009 69: 2523-2530. Published Online First February 24, 2009. doi: 10.1158/0008-5472.CAN-08-2793 [Abstract] [Full Text] [PDF] Supplementary Data  

Natural Killer Cells Require Selectins for Suppression of Subcutaneous Tumors

Olga Sobolev, Patrick Stern, Adam Lacy-Hulbert, and Richard O. Hynes
Cancer Res 2009 69: 2531-2539. Published Online First March 3, 2009. doi: 10.1158/0008-5472.CAN-08-3126 [Abstract] [Full Text] [PDF] Supplementary Data  

Molecular Biology, Pathobiology, and Genetics:

Epidermal Growth Factor Receptor and PTEN Modulate Tissue Factor Expression in Glioblastoma through JunD/Activator Protein-1 Transcriptional Activity

Yuan Rong, Vladimir E. Belozerov, Carol Tucker-Burden, Gang Chen, Donald L. Durden, Jeffrey J. Olson, Erwin G. Van Meir, Nigel Mackman, and Daniel J. Brat
Cancer Res 2009 69: 2540-2549. Published Online First March 10, 2009. doi: 10.1158/0008-5472.CAN-08-1547 [Abstract] [Full Text] [PDF] Supplementary Data  

Sonic Hedgehog Signaling Pathway Is Activated in ALK-Positive Anaplastic Large Cell Lymphoma

Rajesh R. Singh, Jeong Hee Cho-Vega, Yogesh Davuluri, Shuguang Ma, Fatan Kasbidi, Cristiane Milito, Patrick A. Lennon, Elias Drakos, L. Jeffrey Medeiros, Rajyalakshmi Luthra, and Francisco Vega
Cancer Res 2009 69: 2550-2558. Published Online First February 24, 2009. doi: 10.1158/0008-5472.CAN-08-1808 [Abstract] [Full Text] [PDF] Supplementary Data  

MMP13, Birc2 (cIAP1), and Birc3 (cIAP2), Amplified on Chromosome 9, Collaborate with p53 Deficiency in Mouse Osteosarcoma Progression

Ou Ma, Wei-Wen Cai, Lars Zender, Tajhal Dayaram, Jianhe Shen, Alan J. Herron, Scott W. Lowe, Tsz-Kwong Man, Ching C. Lau, and Lawrence A. Donehower
Cancer Res 2009 69: 2559-2567. Published Online First March 10, 2009. doi: 10.1158/0008-5472.CAN-08-2929 [Abstract] [Full Text] [PDF] Supplementary Data  

Functional Genomic Analysis Identified Epidermal Growth Factor Receptor Activation as the Most Common Genetic Event in Oral Squamous Cell Carcinoma

Jim Jinn-Chyuan Sheu, Chun-Hung Hua, Lei Wan, Ying-Ju Lin, Ming-Tsung Lai, Hsien-Chang Tseng, Natini Jinawath, Ming-Hsui Tsai, Nai-Wen Chang, Chin-Fen Lin, Chyi-Chyang Lin, Lie-Jiau Hsieh, Tian-Li Wang, Ie-Ming Shih, and Fuu-Jen Tsai
Cancer Res 2009 69: 2568-2576. Published Online First March 10, 2009. doi: 10.1158/0008-5472.CAN-08-3199 [Abstract] [Full Text] [PDF] Supplementary Data  

A Role for Stroma-Derived Annexin A1 as Mediator in the Control of Genetic Susceptibility to T-Cell Lymphoblastic Malignancies through Prostaglandin E₂ Secretion

Javier Santos, Laura González-Sánchez, María Matabuena-deYzaguirre, María Villa-Morales, Patricia Cozar, Pilar López-Nieva, Pablo Fernández-Navarro, Manuel Fresno, Manuel D. Díaz-Muñoz, Jean-Louis Guenet, Xavier Montagutelli, and José Fernández-Piqueras
Cancer Res 2009 69: 2577-2587. Published Online First February 24, 2009. doi: 10.1158/0008-5472.CAN-08-1821 [Abstract] [Full Text] [PDF] Supplementary Data  

Ras^V12-Mediated Down-regulation of CCAAT/Enhancer Binding Protein β in Immortalized Fibroblasts Requires Loss of p19^Arf and Facilitates Bypass of Oncogene-Induced Senescence

Thomas Sebastian and Peter F. Johnson
Cancer Res 2009 69: 2588-2598. Published Online First March 10, 2009. doi: 10.1158/0008-5472.CAN-08-2312 [Abstract] [Full Text] [PDF]  

U19/Eaf2 Binds to and Stabilizes von Hippel-Lindau Protein

Wuhan Xiao, Junkui Ai, Geoffrey Habermacher, Olga Volpert, Ximing Yang, Ai-yuan Zhang, Junghyun Hahn, Xiaoyan Cai, and Zhou Wang
Cancer Res 2009 69: 2599-2606. Published Online First March 3, 2009. doi: 10.1158/0008-5472.CAN-08-2595 [Abstract] [Full Text] [PDF]  

Identification of Ligand-Induced Proteolytic Cleavage and Ectodomain Shedding of VEGFR-1/FLT1 in Leukemic Cancer Cells

Nader Rahimi, Todd E. Golde, and Rosana D. Meyer
Cancer Res 2009 69: 2607-2614. Published Online First March 10, 2009. doi: 10.1158/0008-5472.CAN-08-2905 [Abstract] [Full Text] [PDF]  

NKX3.1 Activates Expression of Insulin-like Growth Factor Binding Protein-3 to Mediate Insulin-like Growth Factor-I Signaling and Cell Proliferation

Erin Muhlbradt, Ekaterina Asatiani, Elizabeth Ortner, Antai Wang, and Edward P. Gelmann
Cancer Res 2009 69: 2615-2622. Published Online First March 3, 2009. doi: 10.1158/0008-5472.CAN-08-3022 [Abstract] [Full Text] [PDF] Supplementary Data  

The Putative Tumor Suppressor microRNA-101 Modulates the Cancer Epigenome by Repressing the Polycomb Group Protein EZH2

Jeffrey M. Friedman, Gangning Liang, Chun-Chi Liu, Erika M. Wolff, Yvonne C. Tsai, Wei Ye, Xianghong Zhou, and Peter A. Jones
Cancer Res 2009 69: 2623-2629. Published Online First March 3, 2009. doi: 10.1158/0008-5472.CAN-08-3114 [Abstract] [Full Text] [PDF] Supplementary Data  

DDB1 Targets Chk1 to the Cul4 E3 Ligase Complex in Normal Cycling Cells and in Cells Experiencing Replication Stress

Van Leung-Pineda, Jiwon Huh, and Helen Piwnica-Worms
Cancer Res 2009 69: 2630-2637. Published Online First March 10, 2009. doi: 10.1158/0008-5472.CAN-08-3382 [Abstract] [Full Text] [PDF] Supplementary Data  

Hypoxia-Inducible Factor-1 Suppresses Squamous Carcinogenic Progression and Epithelial-Mesenchymal Transition

Marzia Scortegagna, Rebecca J. Martin, Raleigh D. Kladney, Robert G. Neumann, and Jeffrey M. Arbeit
Cancer Res 2009 69: 2638-2646. Published Online First March 10, 2009. doi: 10.1158/0008-5472.CAN-08-3643 [Abstract] [Full Text] [PDF] Supplementary Data  

NADPH Oxidase 4 Contributes to Transformation Phenotype of Melanoma Cells by Regulating G₂-M Cell Cycle Progression

Maki Yamaura, Junji Mitsushita, Shuichi Furuta, Yukiko Kiniwa, Atsuko Ashida, Yasuhumi Goto, Wei H. Shang, Makoto Kubodera, Masayoshi Kato, Minoru Takata, Toshiaki Saida, and Tohru Kamata
Cancer Res 2009 69: 2647-2654. Published Online First March 10, 2009. doi: 10.1158/0008-5472.CAN-08-3745 [Abstract] [Full Text] [PDF] Supplementary Data  

Systems Biology and Emerging Technologies:

Cancer-Specific Transgene Expression Mediated by Systemic Injection of Nanoparticles

Edward J. Chisholm, Georges Vassaux, Pilar Martin-Duque, Raphael Chevre, Olivier Lambert, Bruno Pitard, Andrew Merron, Mark Weeks, Jerome Burnet, Inge Peerlinck, Ming-Shen Dai, Ghassan Alusi, Stephen J. Mather, Katherine Bolton, Ijeoma F. Uchegbu, Andreas G. Schatzlein, and Patrick Baril
Cancer Res 2009 69: 2655-2662. Published Online First March 3, 2009. doi: 10.1158/0008-5472.CAN-08-2657 [Abstract] [Full Text] [PDF] Supplementary Data  

CDC25B Mediates Rapamycin-Induced Oncogenic Responses in Cancer Cells

Run-qiang Chen, Qing-kai Yang, Bing-wen Lu, Wei Yi, Greg Cantin, Yan-ling Chen, Colleen Fearns, John R. Yates, III, and Jiing-Dwan Lee
Cancer Res 2009 69: 2663-2668. Published Online First March 10, 2009. doi: 10.1158/0008-5472.CAN-08-3222 [Abstract] [Full Text] [PDF] Supplementary Data  

Tumor Microenvironment:

Endothelin-1 Stimulates Lymphatic Endothelial Cells and Lymphatic Vessels to Grow and Invade

Francesca Spinella, Emirena Garrafa, Valeriana Di Castro, Laura Rosanò, Maria Rita Nicotra, Arnaldo Caruso, Pier Giorgio Natali, and Anna Bagnato
Cancer Res 2009 69: 2669-2676. Published Online First March 10, 2009. doi: 10.1158/0008-5472.CAN-08-1879 [Abstract] [Full Text] [PDF] Supplementary Data  

The Potential Role of Systemic Buffers in Reducing Intratumoral Extracellular pH and Acid-Mediated Invasion

Ariosto S. Silva, Jose A. Yunes, Robert J. Gillies, and Robert A. Gatenby
Cancer Res 2009 69: 2677-2684. Published Online First March 10, 2009. doi: 10.1158/0008-5472.CAN-08-2394 [Abstract] [Full Text] [PDF] Supplementary Data  

Coordination of Intratumoral Immune Reaction and Human Colorectal Cancer Recurrence

Matthieu Camus, Marie Tosolini, Bernhard Mlecnik, Franck Pagès, Amos Kirilovsky, Anne Berger, Anne Costes, Gabriela Bindea, Pornpimol Charoentong, Patrick Bruneval, Zlatko Trajanoski, Wolf-Herman Fridman, and Jérôme Galon
Cancer Res 2009 69: 2685-2693. Published Online First March 3, 2009. doi: 10.1158/0008-5472.CAN-08-2654 [Abstract] [Full Text] [PDF] Supplementary Data  

Corrections:

Correction: Article on Triterpenes in Astrocytoma Cells

Cancer Res 2009 69: 2694. Published Online First March 10, 2009. doi: 10.1158/0008-5472.CAN-69-6-COR1 [Full Text] [PDF]  

Correction: Article on VCAM-1 and Ovarian Cancer Metastasis

Cancer Res 2009 69: 2694. Published Online First March 10, 2009. doi: 10.1158/0008-5472.CAN-69-6-COR2 [Full Text] [PDF]  

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