Summary: Study identifies mechanisms that impact the efficacy of EGFR inhibitors in drug resistant lung cancer cells.
Summary: Oncolytic engineered measles virus strains warrant further investigation as novel therapeutic agents in the treatment of ovarian cancer.
Summary: A powerful oncogenomics analysis of human and mouse tumors reveals a number of stem cell regulatory genes among new candidate cancer genes that are identified.
Summary: Changes in exon usage (alternate RNA splicing) that occur widely during cancer progression may offer unique new types of prognostic markers.
Summary: Tactics to stimulate immune eradication of stem cell populations in tumors may lead to more durable remissions.
Summary: A mechanism-based understanding of the aggressive behavior of MYCN-amplified neuroblastomas could lead to improvements in prognosis and therapy of these commonly deadly childhood tumors.
Summary: Cycles of hypoxia and reoxygenation in tumors can drive DNA damage and genomic instabilty that promotes malignant development, especially if p53 function is impaired.
Summary: Study suggests that S100A4 stimulates metastasis by attracting T cells and stimulating cytokine production at the site of early pre-malignant tumor.
Summary: ADAMTS1 cleaves thrombospondin 1 more efficiently in the liver versus lung, resulting in significantly different anti-angiogenic activity against metastases to these sites. Thus anti-angiogenic approaches to solid tumor metastases must take into consideration the target host organ environment.
Summary: Synthetic lethal combinations of DNA damage mutations involving ceramide synthetase may help widen the therapeutic index of irradiation and other DNA damage-based therapies.
Summary: Stably propagated epigenetic changes in cancer cells may be as important as acquired genetic alternations in driving tumor development and progression.
Summary: Findings may address ongoing gaps in knowledge concerning the key mutational events in sporadic or familial forms of prostate cancer.
Summary: A useful assay is offered to gain a more precise understanding of how mutations in the breast tumor suppressor BRCA1 affect its function in DNA recombinational repair.
Summary: By tightening the linkage between BRCA1 mutation and upregulation of a key breast cancer growth factor, findings suggest a therapeutic strategy to attack BRCA1 mutant tumors.
Summary: Stress modifier genes that are not part of cancer pathways per se represent a major class of therapeutic targets yet to be fully explored.
Summary: For reasons that remain unclear as yet, individuals with non-O blood types may be at somewhat higher risk for pancreatic cancer.
Summary: Findings from a large case-control study identify a novel genetic susceptibility variants of breast cancer development and progression.
Summary: Simple ‘theranostic’ targets that could not only predict responses to microtubule poisons but also represent therapeutic targets for inhibition may dramatically improve the management of the large number of tumors treated with this important class of oncological agents.
Summary: Therapeutic strategies to augment autophagy, a transient survival tactic that can be turned against cancer cells, may offer novel approaches to degrade cancer cell survival.
Summary: Findings document suspicions that the therapeutic benefits of sunitinib treatment are manifested primarily through anti-angiogenic effects on tumors, rather than on tumor cells themselves.
Summary: Cytokine targeting strategies have had limited impact to date in cancer treatment, but they may find more effective applications in addressing resistance to anti-angiogenic therapy.
Summary: IL-15 is a cytokine of top most interest in cancer vaccine strategies, but as a result of the complex variety of activities it mediates in the immune system the mechanistic basis underlying its benefits to effective vaccine responses are not yet fully understood.
Summary: Findings suggest a strategy to loosen the tumor microenvironment and improve the ability of bulky biological immunotoxins to reach malignant cells in tumors, which are difficult to penetrate due to poor blood circulation and other factors.
Summary: Simple prognostic markers for early-stage breast cancers most frequently diagnosed and often but not always successfully treated remain of interest
Summary: Small molecule agonists of the TRAIL apoptotic pathway may offer a second generation of therapeutic approaches in this area that is currently being explored in clinical trials.
Summary: Sp1 transcription factor targeting yields anti-metastatic benefits that may be especially beneficial in aggressive tumors such as pancreatic cancer.
Summary: Studies of an interleukin that triggers apoptosis of brain tumor cells suggest the benefits of activating a pathway of ER stress in cancer cells as an effective therapeutic strategy to treat brain cancer.
Summary: A novel small molecule strategy to improve pancreatic treatment with the front line chemotherapeutic gemcitabine is rationalized by the findings of this stud.
Summary: Advances in understanding the pivotal regulators of breast cancer cell adhesion may reveal prognostic markers and novel anti-invasive strategies to retard or prevent metastatic progression.
Summary: Unleashing pro-apoptotic effects of an oncogene that drives a class of pediatric soft tissue tumors may offer tactics for therapeutic attack.
Summary: PI3K inhibitors may offer therapeutic promise for cancer treatment, but matching pathway status to patterns of PI3K isoforms to inhibit may be needed to achieve favorable outcomes.
Summary: Drugs that block calcium signaling may have utility in retarding the invasive capacity of glioblastoma, the most aggressive and deadly form of brain cancer that is diagnosed fairly commonly in middle aged as well as elderly patients.
Summary: Non-classical receptors for estrogen modulate proliferation and may represent a new target to treat breast cancer.
Summary: Modifiers of stress processes that integrate multiple signaling pathways may be extremely attractive as a second generation of therapeutic targets in cancer, yet to be explored due to their somewhat more distal connections to disease.
Summary: Bypassing inherent or acquired resistance to the breast cancer drug trastuzumab (Herceptin) represents an important therapeutic goal, given the established benefits of this therapeutic agent.
Summary: Study reveals a novel stem cell determinant that may selectively drive tumor angiogenesis.
Summary: Ion channels represent a class of biological modifiers in epithelial cancers that are little explored but highly tractable to therapeutic targeting
Summary: Findings prompt evaluation of a differentiation-promoting zinc finger transcription factor that can block the growth of brain tumors as a candidate tumor suppressor gene in human brain cancers.
Summary: Bile acid reflux may promote the development of esophageal adenocarcinoma by overproduction of NOX5-S-derived reactive oxygen species.
Summary: Relevant sites of steroidogenesis in prostate cancer may influence disease pathophysiology and therefore the most effective routes of therapeutic attack.
Summary: Fuller understanding of the supports to estrogen mediated proliferation in breast cancer may lead to insights in the basis for variations in the development, progression, and treatment of ER-positive tumors.
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