Cancer Research Annual Meeting 2010
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Contents: February 1, 2010, Volume 70, Issue 3   [Index by Author] 
      Down Reviews
      Down Perspectives
      Down Priority Report
      Down Clinical Studies
      Down Integrated Systems and Technologies
      Down Microenvironment and Immunology
      Down Molecular and Cellular Pathobiology
      Down Prevention and Epidemiology
      Down Therapeutics, Targets, and Chemical Biology
      Down Tumor and Stem Cell Biology
      Down Corrections

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To see an article, click its [Full Text] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

Reviews:Back

Laetitia Aymeric, Lionel Apetoh, François Ghiringhelli, Antoine Tesniere, Isabelle Martins, Guido Kroemer, Mark J. Smyth, and Laurence Zitvogel
Cancer Res 2010 70: 855-858. Published Online First January 19, 2010. doi: 10.1158/0008-5472.CAN-09-3566 [Abstract] [Full Text] [PDF]  

Chi V. Dang
Cancer Res 2010 70: 859-862. Published Online First January 19, 2010. doi: 10.1158/0008-5472.CAN-09-3556 [Abstract] [Full Text] [PDF]  

Perspectives:Back

Laura M. Vecchiarelli-Federico, David Cervi, Mehran Haeri, Yanmei Li, Andras Nagy, and Yaacov Ben-David
Cancer Res 2010 70: 863-867. Published Online First January 26, 2010. doi: 10.1158/0008-5472.CAN-09-3592 [Abstract] [Full Text] [PDF]  

Priority Report:Back

Martin L. Sos, Haridas B. Rode, Stefanie Heynck, Martin Peifer, Florian Fischer, Sabine Klüter, Vijaykumar G. Pawar, Cecile Reuter, Johannes M. Heuckmann, Jonathan Weiss, Lars Ruddigkeit, Matthias Rabiller, Mirjam Koker, Jeffrey R. Simard, Matthäus Getlik, Yuki Yuza, Tzu-Hsiu Chen, Heidi Greulich, Roman K. Thomas, and Daniel Rauh
Cancer Res 2010 70: 868-874. Published Online First January 26, 2010. doi: 10.1158/0008-5472.CAN-09-3106 [Abstract] [Full Text] [PDF] Supplementary Data  

Summary: Study identifies mechanisms that impact the efficacy of EGFR inhibitors in drug resistant lung cancer cells.

Clinical Studies:Back

Evanthia Galanis, Lynn C. Hartmann, William A. Cliby, Harry J. Long, Prema P. Peethambaram, Brigitte A. Barrette, Judith S. Kaur, Paul J. Haluska, Jr., Ileana Aderca, Paula J. Zollman, Jeff A. Sloan, Gary Keeney, Pamela J. Atherton, Karl C. Podratz, Sean C. Dowdy, C. Robert Stanhope, Timothy O. Wilson, Mark J. Federspiel, Kah-Whye Peng, and Stephen J. Russell
Cancer Res 2010 70: 875-882. Published Online First January 26, 2010. doi: 10.1158/0008-5472.CAN-09-2762 [Abstract] [Full Text] [PDF] Supplementary Data  

Summary: Oncolytic engineered measles virus strains warrant further investigation as novel therapeutic agents in the treatment of ovarian cancer.

Integrated Systems and Technologies:Back

Jenny Mattison, Jaap Kool, Anthony G. Uren, Jeroen de Ridder, Lodewyk Wessels, Jos Jonkers, Graham R. Bignell, Adam Butler, Alistair G. Rust, Markus Brosch, Catherine H. Wilson, Louise van der Weyden, David A. Largaespada, Michael R. Stratton, P. Andy Futreal, Maarten van Lohuizen, Anton Berns, Lara S. Collier, Tim Hubbard, and David J. Adams
Cancer Res 2010 70: 883-895. Published Online First January 26, 2010. doi: 10.1158/0008-5472.CAN-09-1737 [Abstract] [Full Text] [PDF] Supplementary Data  

Summary: A powerful oncogenomics analysis of human and mouse tumors reveals a number of stem cell regulatory genes among new candidate cancer genes that are identified.

Martin Dutertre, Magali Lacroix-Triki, Keltouma Driouch, Pierre de la Grange, Lise Gratadou, Samantha Beck, Stefania Millevoi, Jamal Tazi, Rosette Lidereau, Stephan Vagner, and Didier Auboeuf
Cancer Res 2010 70: 896-905. Published Online First January 26, 2010. doi: 10.1158/0008-5472.CAN-09-2703 [Abstract] [Full Text] [PDF] Supplementary Data  

Summary: Changes in exon usage (alternate RNA splicing) that occur widely during cancer progression may offer unique new types of prognostic markers.

Microenvironment and Immunology:Back

Melinda A. Biernacki, Ovidiu Marina, Wandi Zhang, Fenglong Liu, Ingmar Bruns, Ann Cai, Donna Neuberg, Christine M. Canning, Edwin P. Alyea, Robert J. Soiffer, Vladimir Brusic, Jerome Ritz, and Catherine J. Wu
Cancer Res 2010 70: 906-915. Published Online First January 26, 2010. doi: 10.1158/0008-5472.CAN-09-2303 [Abstract] [Full Text] [PDF] Supplementary Data  

Summary: Tactics to stimulate immune eradication of stem cell populations in tumors may lead to more durable remissions.

Matteo Forloni, Sonia Albini, Maria Zaira Limongi, Loredana Cifaldi, Renata Boldrini, Maria Rita Nicotra, Giuseppe Giannini, Pier Giorgio Natali, Patrizio Giacomini, and Doriana Fruci
Cancer Res 2010 70: 916-924. Published Online First January 26, 2010. doi: 10.1158/0008-5472.CAN-09-2582 [Abstract] [Full Text] [PDF] Supplementary Data  

Summary: A mechanism-based understanding of the aggressive behavior of MYCN-amplified neuroblastomas could lead to improvements in prognosis and therapy of these commonly deadly childhood tumors.

Isabel M. Pires, Zuzana Bencokova, Manuela Milani, Lisa K. Folkes, Ji-Liang Li, Mike R. Stratford, Adrian L. Harris, and Ester M. Hammond
Cancer Res 2010 70: 925-935. Published Online First January 26, 2010. doi: 10.1158/0008-5472.CAN-09-2715 [Abstract] [Full Text] [PDF] Supplementary Data  

Summary: Cycles of hypoxia and reoxygenation in tumors can drive DNA damage and genomic instabilty that promotes malignant development, especially if p53 function is impaired.

Birgitte Grum-Schwensen, Jörg Klingelhöfer, Mariam Grigorian, Kasper Almholt, Boye Schnack Nielsen, Eugene Lukanidin, and Noona Ambartsumian
Cancer Res 2010 70: 936-947. Published Online First January 26, 2010. doi: 10.1158/0008-5472.CAN-09-3220 [Abstract] [Full Text] [PDF] Supplementary Data  

Summary: Study suggests that S100A4 stimulates metastasis by attracting T cells and stimulating cytokine production at the site of early pre-malignant tumor.

Yoon-Jin Lee, Moritz Koch, Daniel Karl, Antoni X. Torres-Collado, Namali T. Fernando, Courtney Rothrock, Darshini Kuruppu, Sandra Ryeom, M. Luisa Iruela-Arispe, and Sam S. Yoon
Cancer Res 2010 70: 948-956. Published Online First January 26, 2010. doi: 10.1158/0008-5472.CAN-09-3094 [Abstract] [Full Text] [PDF] Supplementary Data  

Summary: ADAMTS1 cleaves thrombospondin 1 more efficiently in the liver versus lung, resulting in significantly different anti-angiogenic activity against metastases to these sites. Thus anti-angiogenic approaches to solid tumor metastases must take into consideration the target host organ environment.

Molecular and Cellular Pathobiology:Back

Jimmy A. Rotolo, Judith Mesicek, Jerzy Maj, Jean-Philip Truman, Adriana Haimovitz-Friedman, Richard Kolesnick, and Zvi Fuks
Cancer Res 2010 70: 957-967. Published Online First January 19, 2010. doi: 10.1158/0008-5472.CAN-09-1562 [Abstract] [Full Text] [PDF] Supplementary Data  

Summary: Synthetic lethal combinations of DNA damage mutations involving ceramide synthetase may help widen the therapeutic index of irradiation and other DNA damage-based therapies.

Panagiotis Papageorgis, Arthur W. Lambert, Sait Ozturk, Fangming Gao, Hongjie Pan, Upender Manne, Yuriy O. Alekseyev, Arunthathi Thiagalingam, Hamid M. Abdolmaleky, Marc Lenburg, and Sam Thiagalingam
Cancer Res 2010 70: 968-978. Published Online First January 19, 2010. doi: 10.1158/0008-5472.CAN-09-1872 [Abstract] [Full Text] [PDF] Supplementary Data  

Summary: Stably propagated epigenetic changes in cancer cells may be as important as acquired genetic alternations in driving tumor development and progression.

Martin K. Thomsen, Laurence Ambroisine, Sarah Wynn, Kathryn S.E. Cheah, Christopher S. Foster, Gabrielle Fisher, Daniel M. Berney, Henrik Møller, Victor E. Reuter, Peter Scardino, Jack Cuzick, Narasimhan Ragavan, Paras B. Singh, Francis L. Martin, Christopher M. Butler, Colin S. Cooper, Amanda Swain, and on behalf of the Transatlantic Prostate Group
Cancer Res 2010 70: 979-987. Published Online First January 26, 2010. doi: 10.1158/0008-5472.CAN-09-2370 [Abstract] [Full Text] [PDF] Supplementary Data  

Summary: Findings may address ongoing gaps in knowledge concerning the key mutational events in sporadic or familial forms of prostate cancer.

Derek J.R. Ransburgh, Natsuko Chiba, Chikashi Ishioka, Amanda Ewart Toland, and Jeffrey D. Parvin
Cancer Res 2010 70: 988-995. Published Online First January 26, 2010. doi: 10.1158/0008-5472.CAN-09-2850 [Abstract] [Full Text] [PDF] Supplementary Data  

Summary: A useful assay is offered to gain a more precise understanding of how mutations in the breast tumor suppressor BRCA1 affect its function in DNA recombinational repair.

Ekaterina P. Lamber, Andrew A. Horwitz, and Jeffrey D. Parvin
Cancer Res 2010 70: 996-1005. Published Online First January 26, 2010. doi: 10.1158/0008-5472.CAN-09-2842 [Abstract] [Full Text] [PDF] Supplementary Data  

Summary: By tightening the linkage between BRCA1 mutation and upregulation of a key breast cancer growth factor, findings suggest a therapeutic strategy to attack BRCA1 mutant tumors.

Prevention and Epidemiology:Back

Jun Shen, Roberto J. Barrios, and Anil K. Jaiswal
Cancer Res 2010 70: 1006-1014. Published Online First January 26, 2010. doi: 10.1158/0008-5472.CAN-09-2938 [Abstract] [Full Text] [PDF]  

Summary: Stress modifier genes that are not part of cancer pathways per se represent a major class of therapeutic targets yet to be fully explored.

Brian M. Wolpin, Peter Kraft, Myron Gross, Kathy Helzlsouer, H. Bas Bueno-de-Mesquita, Emily Steplowski, Rachael Z. Stolzenberg-Solomon, Alan A. Arslan, Eric J. Jacobs, Andrea LaCroix, Gloria Petersen, Wei Zheng, Demetrius Albanes, Naomi E. Allen, Laufey Amundadottir, Garnet Anderson, Marie-Christine Boutron-Ruault, Julie E. Buring, Federico Canzian, Stephen J. Chanock, Sandra Clipp, John Michael Gaziano, Edward L. Giovannucci, Göran Hallmans, Susan E. Hankinson, Robert N. Hoover, David J. Hunter, Amy Hutchinson, Kevin Jacobs, Charles Kooperberg, Shannon M. Lynch, Julie B. Mendelsohn, Dominique S. Michaud, Kim Overvad, Alpa V. Patel, Aleksandar Rajkovic, Maria-José Sanchéz, Xiao-Ou Shu, Nadia Slimani, Gilles Thomas, Geoffrey S. Tobias, Dimitrios Trichopoulos, Paolo Vineis, Jarmo Virtamo, Jean Wactawski-Wende, Kai Yu, Anne Zeleniuch-Jacquotte, Patricia Hartge, and Charles S. Fuchs
Cancer Res 2010 70: 1015-1023. Published Online First January 26, 2010. doi: 10.1158/0008-5472.CAN-09-2993 [Abstract] [Full Text] [PDF] Supplementary Data  

Summary: For reasons that remain unclear as yet, individuals with non-O blood types may be at somewhat higher risk for pancreatic cancer.

Fangfang Song, Ping Ji, Hong Zheng, Fengju Song, Yingmei Wang, Xishan Hao, Qingyi Wei, Wei Zhang, and Kexin Chen
Cancer Res 2010 70: 1024-1032. Published Online First January 26, 2010. doi: 10.1158/0008-5472.CAN-09-3742 [Abstract] [Full Text] [PDF] Supplementary Data  

Summary: Findings from a large case-control study identify a novel genetic susceptibility variants of breast cancer development and progression.

Therapeutics, Targets, and Chemical Biology:Back

Jason Doles and Michael T. Hemann
Cancer Res 2010 70: 1033-1041. Published Online First January 26, 2010. doi: 10.1158/0008-5472.CAN-09-2113 [Abstract] [Full Text] [PDF] Supplementary Data  

Summary: Simple ‘theranostic’ targets that could not only predict responses to microtubule poisons but also represent therapeutic targets for inhibition may dramatically improve the management of the large number of tumors treated with this important class of oncological agents.

Alexandre Puissant, Guillaume Robert, Nina Fenouille, Frederic Luciano, Jill-Patrice Cassuto, Sophie Raynaud, and Patrick Auberger
Cancer Res 2010 70: 1042-1052. Published Online First January 26, 2010. doi: 10.1158/0008-5472.CAN-09-3537 [Abstract] [Full Text] [PDF] Supplementary Data  

Summary: Therapeutic strategies to augment autophagy, a transient survival tactic that can be turned against cancer cells, may offer novel approaches to degrade cancer cell survival.

Dan Huang, Yan Ding, Yan Li, Wang-Mei Luo, Zhong-Fa Zhang, John Snider, Kristin VandenBeldt, Chao-Nan Qian, and Bin Tean Teh
Cancer Res 2010 70: 1053-1062. Published Online First January 26, 2010. doi: 10.1158/0008-5472.CAN-09-3722 [Abstract] [Full Text] [PDF] Supplementary Data  

Summary: Findings document suspicions that the therapeutic benefits of sunitinib treatment are manifested primarily through anti-angiogenic effects on tumors, rather than on tumor cells themselves.

Dan Huang, Yan Ding, Ming Zhou, Brian I. Rini, David Petillo, Chao-Nan Qian, Richard Kahnoski, P. Andrew Futreal, Kyle A. Furge, and Bin Tean Teh
Cancer Res 2010 70: 1063-1071. Published Online First January 26, 2010. doi: 10.1158/0008-5472.CAN-09-3965 [Abstract] [Full Text] [PDF] Supplementary Data  

Summary: Cytokine targeting strategies have had limited impact to date in cancer treatment, but they may find more effective applications in addressing resistance to anti-angiogenic therapy.

Jason C. Steel, Charmaine A. Ramlogan, Ping Yu, Yoshio Sakai, Guido Forni, Thomas A. Waldmann, and John C. Morris
Cancer Res 2010 70: 1072-1081. Published Online First January 19, 2010. doi: 10.1158/0008-5472.CAN-09-1301 [Abstract] [Full Text] [PDF]  

Summary: IL-15 is a cytokine of top most interest in cancer vaccine strategies, but as a result of the complex variety of activities it mediates in the immune system the mechanistic basis underlying its benefits to effective vaccine responses are not yet fully understood.

Yujian Zhang, Johanna K. Hansen, Laiman Xiang, Seiji Kawa, Masanori Onda, Mitchell Ho, Raffit Hassan, and Ira Pastan
Cancer Res 2010 70: 1082-1089. Published Online First January 26, 2010. doi: 10.1158/0008-5472.CAN-09-2405 [Abstract] [Full Text] [PDF]  

Summary: Findings suggest a strategy to loosen the tumor microenvironment and improve the ability of bulky biological immunotoxins to reach malignant cells in tumors, which are difficult to penetrate due to poor blood circulation and other factors.

Hayley D. McKeen, Christopher Byrne, Puthen V. Jithesh, Christopher Donley, Andrea Valentine, Anita Yakkundi, Martin O'Rourke, Charles Swanton, Helen O. McCarthy, David G. Hirst, and Tracy Robson
Cancer Res 2010 70: 1090-1100. Published Online First January 26, 2010. doi: 10.1158/0008-5472.CAN-09-2515 [Abstract] [Full Text] [PDF] Supplementary Data  

Summary: Simple prognostic markers for early-stage breast cancers most frequently diagnosed and often but not always successfully treated remain of interest

Valeria Pavet, Julien Beyrath, Christophe Pardin, Alexandre Morizot, Marie-Charlotte Lechner, Jean-Paul Briand, Miriam Wendland, Wolfgang Maison, Sylvie Fournel, Olivier Micheau, Gilles Guichard, and Hinrich Gronemeyer
Cancer Res 2010 70: 1101-1110. Published Online First January 26, 2010. doi: 10.1158/0008-5472.CAN-09-2889 [Abstract] [Full Text] [PDF] Supplementary Data  

Summary: Small molecule agonists of the TRAIL apoptotic pathway may offer a second generation of therapeutic approaches in this area that is currently being explored in clinical trials.

Zhiliang Jia, Yong Gao, Liwei Wang, Qiang Li, Jun Zhang, Xiangdong Le, Daoyan Wei, James C. Yao, David Z. Chang, Suyun Huang, and Keping Xie
Cancer Res 2010 70: 1111-1119. Published Online First January 19, 2010. doi: 10.1158/0008-5472.CAN-09-3282 [Abstract] [Full Text] [PDF] Supplementary Data  

Summary: Sp1 transcription factor targeting yields anti-metastatic benefits that may be especially beneficial in aggressive tumors such as pancreatic cancer.

Adly Yacoub, Hossein A. Hamed, Jeremy Allegood, Clint Mitchell, Sarah Spiegel, Maciej S. Lesniak, Besim Ogretmen, Rupesh Dash, Devanand Sarkar, William C. Broaddus, Steven Grant, David T. Curiel, Paul B. Fisher, and Paul Dent
Cancer Res 2010 70: 1120-1129. Published Online First January 26, 2010. doi: 10.1158/0008-5472.CAN-09-4043 [Abstract] [Full Text] [PDF] Supplementary Data  

Summary: Studies of an interleukin that triggers apoptosis of brain tumor cells suggest the benefits of activating a pathway of ER stress in cancer cells as an effective therapeutic strategy to treat brain cancer.

Tumor and Stem Cell Biology:Back

Jocelyn Logan-Collins, Ryan M. Thomas, Peter Yu, Dawn Jaquish, Evangeline Mose, Randall French, William Stuart, Rebecca McClaine, Bruce Aronow, Robert M. Hoffman, Susan E. Waltz, and Andrew M. Lowy
Cancer Res 2010 70: 1130-1140. Published Online First January 26, 2010. doi: 10.1158/0008-5472.CAN-09-0761 [Abstract] [Full Text] [PDF]  

Summary: A novel small molecule strategy to improve pancreatic treatment with the front line chemotherapeutic gemcitabine is rationalized by the findings of this stud.

Luke Truitt, Tanya Freywald, John DeCoteau, Nigel Sharfe, and Andrew Freywald
Cancer Res 2010 70: 1141-1153. Published Online First January 19, 2010. doi: 10.1158/0008-5472.CAN-09-1710 [Abstract] [Full Text] [PDF] Supplementary Data  

Summary: Advances in understanding the pivotal regulators of breast cancer cell adhesion may reveal prognostic markers and novel anti-invasive strategies to retard or prevent metastatic progression.

Eun Jung Sohn, Hongjie Li, Karen Reidy, Lisa F. Beers, Barbara L. Christensen, and Sean Bong Lee
Cancer Res 2010 70: 1154-1163. Published Online First January 26, 2010. doi: 10.1158/0008-5472.CAN-09-1993 [Abstract] [Full Text] [PDF] Supplementary Data  

Summary: Unleashing pro-apoptotic effects of an oncogene that drives a class of pediatric soft tissue tumors may offer tactics for therapeutic attack.

Kyle A. Edgar, Jeffrey J. Wallin, Megan Berry, Leslie B. Lee, Wei Wei Prior, Deepak Sampath, Lori S. Friedman, and Marcia Belvin
Cancer Res 2010 70: 1164-1172. Published Online First January 26, 2010. doi: 10.1158/0008-5472.CAN-09-2525 [Abstract] [Full Text] [PDF] Supplementary Data  

Summary: PI3K inhibitors may offer therapeutic promise for cancer treatment, but matching pathway status to patterns of PI3K isoforms to inhibit may be needed to achieve favorable outcomes.

Sang Soo Kang, Kyung-Seok Han, Bo Mi Ku, Yeon Kyung Lee, Jinpyo Hong, Hye Young Shin, Antoine G. Almonte, Dong Ho Woo, Daniel J. Brat, Eun Mi Hwang, Seung Hyun Yoo, Chun Kee Chung, Sung-Hye Park, Sun Ha Paek, Eun Joo Roh, Sung joong Lee, Jae-Yong Park, Stephen F. Traynelis, and C. Justin Lee
Cancer Res 2010 70: 1173-1183. Published Online First January 26, 2010. doi: 10.1158/0008-5472.CAN-09-2886 [Abstract] [Full Text] [PDF] Supplementary Data  

Summary: Drugs that block calcium signaling may have utility in retarding the invasive capacity of glioblastoma, the most aggressive and deadly form of brain cancer that is diagnosed fairly commonly in middle aged as well as elderly patients.

Eric A. Ariazi, Eugen Brailoiu, Smitha Yerrum, Heather A. Shupp, Michael J. Slifker, Heather E. Cunliffe, Michael A. Black, Anne L. Donato, Jeffrey B. Arterburn, Tudor I. Oprea, Eric R. Prossnitz, Nae J. Dun, and V. Craig Jordan
Cancer Res 2010 70: 1184-1194. Published Online First January 19, 2010. doi: 10.1158/0008-5472.CAN-09-3068 [Abstract] [Full Text] [PDF] Supplementary Data  

Summary: Non-classical receptors for estrogen modulate proliferation and may represent a new target to treat breast cancer.

David Romano, David Matallanas, Gregory Weitsman, Christian Preisinger, Tony Ng, and Walter Kolch
Cancer Res 2010 70: 1195-1203. Published Online First January 19, 2010. doi: 10.1158/0008-5472.CAN-09-3147 [Abstract] [Full Text] [PDF] Supplementary Data  

Summary: Modifiers of stress processes that integrate multiple signaling pathways may be extremely attractive as a second generation of therapeutic targets in cancer, yet to be explored due to their somewhat more distal connections to disease.

Xiaoping Huang, Lizhi Gao, Shuiliang Wang, James L. McManaman, Ann D. Thor, XiaoHe Yang, Francisco J. Esteva, and Bolin Liu
Cancer Res 2010 70: 1204-1214. Published Online First January 26, 2010. doi: 10.1158/0008-5472.CAN-09-3321 [Abstract] [Full Text] [PDF] Supplementary Data  

Summary: Bypassing inherent or acquired resistance to the breast cancer drug trastuzumab (Herceptin) represents an important therapeutic goal, given the established benefits of this therapeutic agent.

Yumi Nagahama, Masaya Ueno, Satoru Miyamoto, Eiichi Morii, Takashi Minami, Naoki Mochizuki, Hideyuki Saya, and Nobuyuki Takakura
Cancer Res 2010 70: 1215-1224. Published Online First January 26, 2010. doi: 10.1158/0008-5472.CAN-09-3662 [Abstract] [Full Text] [PDF] Supplementary Data  

Summary: Study reveals a novel stem cell determinant that may selectively drive tumor angiogenesis.

Michaël Monet, V'yacheslav Lehen'kyi, Florian Gackiere, Virginie Firlej, Matthieu Vandenberghe, Morad Roudbaraki, Dimitra Gkika, Albin Pourtier, Gabriel Bidaux, Christian Slomianny, Philippe Delcourt, François Rassendren, Jean-Pierre Bergerat, Jocelyn Ceraline, Florence Cabon, Sandrine Humez, and Natalia Prevarskaya
Cancer Res 2010 70: 1225-1235. Published Online First January 26, 2010. doi: 10.1158/0008-5472.CAN-09-2205 [Abstract] [Full Text] [PDF]  

Summary: Ion channels represent a class of biological modifiers in epithelial cancers that are little explored but highly tractable to therapeutic targeting

Valérie M. Tatard, Chaomei Xiang, Jaclyn A. Biegel, and Nadia Dahmane
Cancer Res 2010 70: 1236-1246. Published Online First January 26, 2010. doi: 10.1158/0008-5472.CAN-09-2249 [Abstract] [Full Text] [PDF] Supplementary Data  

Summary: Findings prompt evaluation of a differentiation-promoting zinc finger transcription factor that can block the growth of brain tumors as a candidate tumor suppressor gene in human brain cancers.

Jie Hong, Jose Behar, Jack Wands, Murray Resnick, Li Juan Wang, Ronald A. DeLellis, David Lambeth, and Weibiao Cao
Cancer Res 2010 70: 1247-1255. Published Online First January 19, 2010. doi: 10.1158/0008-5472.CAN-09-2774 [Abstract] [Full Text] [PDF] Supplementary Data  

Summary: Bile acid reflux may promote the development of esophageal adenocarcinoma by overproduction of NOX5-S-derived reactive oxygen species.

Johannes Hofland, Wytske M. van Weerden, Natasja F.J. Dits, Jacobie Steenbergen, Geert J.L.H. van Leenders, Guido Jenster, Fritz H. Schröder, and Frank H. de Jong
Cancer Res 2010 70: 1256-1264. Published Online First January 19, 2010. doi: 10.1158/0008-5472.CAN-09-2092 [Abstract] [Full Text] [PDF] Supplementary Data  

Summary: Relevant sites of steroidogenesis in prostate cancer may influence disease pathophysiology and therefore the most effective routes of therapeutic attack.

Nina Gustafsson, Chunyan Zhao, Jan-Åke Gustafsson, and Karin Dahlman-Wright
Cancer Res 2010 70: 1265-1274. Published Online First January 26, 2010. doi: 10.1158/0008-5472.CAN-09-2674 [Abstract] [Full Text] [PDF] Supplementary Data  

Summary: Fuller understanding of the supports to estrogen mediated proliferation in breast cancer may lead to insights in the basis for variations in the development, progression, and treatment of ER-positive tumors.

Corrections:Back

Correction: Antibody-Drug Conjugates for the Treatment of Non-Hodgkin's Lymphoma: Target and Linker-Drug Selection

Cancer Res 2010 70: 1275. Published Online First January 26, 2010. doi: 10.1158/0008-5472.CAN-09-4551 [Full Text] [PDF]  

Correction: An A13 Repeat within the 3'-Untranslated Region of Epidermal Growth Factor Receptor (EGFR) Is Frequently Mutated in Microsatellite Instability Colon Cancers and Is Associated with Increased EGFR Expression

Cancer Res 2010 70: 1275. Published Online First January 26, 2010. doi: 10.1158/0008-5472.CAN-09-4496 [Full Text] [PDF]  

Correction: Glioblastoma Cells Require Glutamate Dehydrogenase to Survive Impairments of Glucose Metabolism or Akt Signaling

Cancer Res 2010 70: 1275. Published Online First January 26, 2010. doi: 10.1158/0008-5472.CAN-09-4497 [Full Text] [PDF]  

To see an article, click its [Full Text] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2010 by the American Association for Cancer Research.