PT  - JOURNAL ARTICLE
AU  - Schiappacasse Cocio, Guido V.
AU  - Schiappacasse, Enrico D.
TI  - Is Adjuvant Chemotherapy Efficient in Colon Cancer with High Microsatellite Instability? A Look Towards the Future
AID  - 10.1158/0008-5472.CAN-18-2991
DP  - 2019 Feb 01
TA  - Cancer Research
PG  - 441--444
VI  - 79
IP  - 3
4099  - http://cancerres.aacrjournals.org/content/79/3/441.short
4100  - http://cancerres.aacrjournals.org/content/79/3/441.full
SO  - Cancer Res2019 Feb 01; 79
AB  - The high microsatellite instability (MSI-H) is frequently observed in localized colorectal adenocarcinoma. MSI-H is a good prognostic factor in nonmetastatic colon adenocarcinoma. However, MSI-H is not a predictive factor because it is not related with better survival in patients with colon cancer with adjuvant chemotherapy. MSI-H should be a predictive factor because it is associated with a higher expression of enzymes, which are inhibited by cytotoxic agents. Here, we analyze this controversy. We conclude MSI-H is not a predictive factor because the adjuvant therapy based on traditional cytotoxic agents does not act on either immune signaling pathways or BRAF mutation.