Table 1

Body weights of male F344 rats given exisulind during the initiation and postinitiation period and promotion/progression period

Experimental groupNo. of animals/groupBody weights (g) of rats on experimental diets
Week 0Week 1Week 4Week 12Week 24Week 36Week 44Week 52
AOM-treated group
 Control diet36115 ± 10a150 ± 12224 ± 14323 ± 22395 ± 25422 ± 27437 ± 38430 ± 40
 Exisulind, 0.06%b36110 ± 10143 ± 14c,1210 ± 16c,3300 ± 21c,3374 ± 26c,2416 ± 28436 ± 30431 ± 29
 Exisulind, 0.12%b36114 ± 8131 ± 11c,3186 ± 16c,3277 ± 21c,4347 ± 24c,4395 ± 25c,3423 ± 26417 ± 25
 Exisulind, 0.12%d36116 ± 8152 ± 10224 ± 11321 ± 18372 ± 24c,3406 ± 31c,2430 ± 34427 ± 35
Vehicle-treated group
 Control diet6113 ± 9147 ± 11231 ± 8340 ± 13419 ± 15463 ± 12481 ± 12484 ± 14
 Exisulind, 0.12%b6109 ± 9128 ± 12c,1204 ± 18c,3283 ± 20c,3357 ± 24c,3396 ± 22c,4408 ± 27c,3421 ± 25c,2
  • a Mean ± SD.

  • b Animals were given exisulind 2 weeks before, during, and after carcinogen or vehicle treatment until the end of the study (initiation and postinitiation period).

  • c Significantly different from the control diet group. 1, P< 0.05

  • c Significantly different from the control diet group.2, P< 0.01

  • c Significantly different from the control diet group. 3, P< 0.001

  • c Significantly different from the control diet group. 4, P< 0.0001.

  • d Animals were given exisulind beginning 14 weeks after the second dose of carcinogen until the end of the study (promotion/progression period).