Table 3

Modulating effects of dietary exisulind on apoptosis in colon tumors

Experimental groupApoptotic index (%)a
Control diet5.33 ± 0.61c
Exisulind, 0.06%b8.13 ± 0.90d,1
Exisulind, 0.12%b9.50 ± 1.20d,2
Exisulind, 0.12%e4.37 ± 0.72
  • a Apoptotic index represents the percentage of cells exhibiting apoptosis.

  • b Animals were given exisulind 2 weeks before, during, and after carcinogen treatment and until termination of the study (initiation and postinitiation periods).

  • c Mean ± SE (n = 10).

  • d Significantly different from the control diet group. 1, P < 0.05.

  • d Significantly different from the control diet group. 2, P < 0.01.

  • e Animals were given exisulind during beginning 14 weeks after the second dose of carcinogen until the end of the study (promotion/progression period).