Table 2

Percentage of transgenic mice with hyperplasia, dysplasia, and cancerous skin epitheliuma

Grade
IIIIIIIV
Control diet2550214
Diet + I3C444880
  • a K14-HPV16 mice were implanted every 60 days with 17β-estradiol (0.125 mg per 60-day release) and fed control diet or diet supplemented with 2000 ppm I3C. Mice were euthanized 24 weeks later. Skin from ear was fixed, processed for histology, stained (H&E) and evaluated for hyperplasia (grade I), moderate dysplasia (grade II), severe dysplasia (grade III), and cancer (grade IV). The number of mice in control diet group was 24, and the number of mice that were fed the I3C-supplemented diet was 23.