Table 4

Toxicity in mice e23 dsFv immunotoxinsa

ImmunotoxinDose (mg/kg)
0.30.40.50.6
e23 dsFv-PE380/32/64/66/6b
e23 (dsFv)2-PE380/30/31/33/3
  • a Groups of six or three athymic nude mice were injected through tail vein with 200 μl of escalating doses of immunotoxins diluted in PBS-HSA (0.2%). Animals were observed for 1 week.

  • b No. of dead mice/total no. of animals in treatment group.