Table 3

Inhibition by dietary chemopreventive agents of the formation of DNA adducts and hemoglobin adducts in Sprague-Dawley rats treated with a single intragastric administration of DMBA (12 mg/kg body weight) and of tumor yield in rats of the same strain treated with a single intragastric administration of DMBA (15 mg/kg body weight)

Chemopreventive agent (dietary dose)% inhibition
DNA adductsaHemoglobin adductsbMammary tumorsb
LiverMammaryIncidenceMultiplicity
5,6-BF(1650 ppm)96.5c83.5c80.0c82.4c92.6c
1,2-D3T(600 ppm)68.5c50.2c44.0c47.1c80.0c
BHA(5000 ppm)46.5c29.005.97.4
  • a This study.

  • b L. L. Song et al., manuscript in preparation (see Footnote 4 ).

  • c Statistically significant inhibition.