Table 2

Enhancement of invasion of bone metastasizing cells by osteonectin

Results are expressed as fold increase in invasive ability. Various cancer cell lines were examined using the following: b-ON (25 ng/well), p-ONa(60 ng/well), OPb (25 ng/well) and BMPc-4 (25 ng/well), as compared to the negative control (RPMI-medium).
Fold increase b-ON/negdFold increase p-ON/negFold increase OP/negFold increase BMP-4/neg
DU-1454.03.50.81.1
PC-34.03.51.81.5
MDA-MB-2316.04.02.01.0
B16-F100.31.13.22.2
HT10801.00.32.31.6
3T3 ras1.00
  • a p-ON, platelet osteonectin.

  • b OP, osteopontin.

  • c BMP, bone morphogenetic protein.

  • d neg, negative.