Table 1

HIF-1α protein expression in normal human tissues

TissuesNa++++++++++Positive cells
Adrenal853Cortical cells
Fetal liver11Hepatocytes
Kidney9612Distal tubular epithelium
Pancreas1174Acinar cells
Spleen1091Proliferating B cells
Testis77Seminiferous tubules
Tonsil3111Proliferating B cells
Brain1010
Breast1818
Heart77
Large intestine2424
Liver1515
Lung1010
Ovary1010
Pituitary22
Placenta22
Prostate1212
Small intestine11
Stomach11
Thyroid1010
Uterus33
Total17415391110
  • a N, number of cases analyzed; −, no staining; +, nuclear staining in less than 1% of cells; ++, in 1–10% of cells; +++, in 10–50%; ++++, greater than 50%.