Table 3

Relationship between expression of HIF-1α and p53, bcl-2, and Ki67 in human cancersa

Number of cases in each category are shown.
p53bcl-2Ki67 LI (%)
++<55–1515–50>50
HIF-1α (−)a38112421381026
HIF-1α (+/++)39829873
HIF-1α (+++/++++)7712202833
P < 0.01bP = 0.05bP < 0.001c
  • a −, no staining; +, nuclear staining in less than 1% of cells; ++, in 1–10% of cells; +++, in 10–50%; ++++, greater than 50%.

  • b Kruskal-Wallis test.

  • c Nonparametric Jonckhere-Terpstra test.