Table 4

Proportion of cancers showing greater than 10% of cells positive by immunohistochemistry

Germline mutation statusNominal P valuesb
AntibodyaBRCA1 mutation carriersBRCA2 mutation carriersControl cancersA1 vs. A2A1 vs. CA2 vs. C
p537/101/99/20 0.02 0.30.1
p217/106/96/201.00.060.1
Cyclin D13/95/919/190.6 <0.001 0.01
bcl-23/105/97/180.40.70.5
Ki-67c4/70/91/19 0.02 0.01 1.0
PCNA8/88/810/131.00.30.3
c-erbB-24/107/918/200.2 0.01 0.5
EGFR1/100/92/201.01.01.0
ER1/106/911/20 0.02 0.02 0.7
PR1/104/96/200.10.40.7
pS21/103/97/200.30.21.0
Cathepsin D2/87/98/170.060.40.2
E-cadherin7/87/710/141.00.60.3
β-Catenin7/84/88/110.30.60.4
  • a Not all of the cases could be stained for each antibody because of the unavailability of tissue.

  • b P shown in bold type are nominally significant at the 0.05 level.

  • c Cutoff for Ki-67 staining was 50% of cells positive by immunohistochemistry.