Table 2

The effect of IGF-II supply on adenoma diameter

Intestines were processed as for Table 1<$REFLINK> and adenoma visualized with a dissecting microscope (×10–30) and size determined using fine calipers. Genotypes with ApcMin/+ are shown only. Values are means ± SD. Statistical comparison between genotypes with normal and altered IGF-II supply was done with the Mann Whitney test.

GenotypeIGF-II supplynAdenoma small intestineAdenoma colon
<2 mm2–4 mm>4 mm<2 mm2–4 mm>4 mm
Apc× K10Igf2/+
Apc,+/+Normal249.5 ± 5.73.6 ± 3.30.6 ± 0.70.3 ± 0.50.2 ± 0.50.2 ± 0.5
Apc,K10Igf2/+Increase1712.8 ± 9.7a4.9 ± 3.9a1.0 ± 1.2a5.8 ± 4.6b3.6 ± 3.5b2.3 ± 2.7b
Ratio (Apc,K10Igf2/+: Apc, +/+)1.351.361.6719.3418.011.5
Apc×Igf2+m/−p
Apc,Igf2Normal1810.5 ± 6.715.3 ± 15.35.9 ± 5.30.6 ± 0.70.6 ± 1.40.6 ± 1.2
Apc,Igf2Reduced144.5 ± 3.5c2.1 ± 2.2b0.7 ± 0.9c0.5 ± 0.8a0.6 ± 1.0a0.8 ± 2.4a
Ratio (Apc,Igf2:Apc,Igf2)0.430.140.12 0.831 1.3
  • a Not significant.

  • b P < 0.0001.

  • c P < 0.001.