Table 3

Histological evaluation of colonic adenoma from (ApcMin/+ × K10Igf2/+) cross

Histopathology classificationGenotype
Apc,+/+ na = 8 % (a/A)Apc,K10Igf2/+ n = 17 % (a/A)
Adenoma100 (11/11)100 (46/46)
+ >50% carcinoma in situb18 (2/11)41 (19/46)
+ Stromal expansion/invasionc9 (1/11)28 (13/46)
  • a n, number of animals; a, number of adenoma with feature; A, total adenoma number.

  • b Area occupying a representative 5 μm section through center of adenoma.

  • c Area visualized in any section through an adenoma.