Table 1

Brain tumor-associated gene products identified by DIA

From the 28 cDNAs that were identified by this method, 9 represented genes with sequence homology to known genes in the GenBank database. Shown below are the clone number and the known or putative function of each gene product.

CloneGenBank IDFunction
L2, L6Human GFAPGlial fibrillary acidic protein; expressed in astrocytes; used as marker for gliomas
L5Human granulinPeptide isolated from human granulocytes; autocrine growth factor for teratoma-derived PC cells; mitogen for 3T3 fibroblasts
L9GAPDHGlyceraldehyde-3-phosphate dehydrogenase; glycolytic enzyme; increased in lung cancer; putative role in apoptosis and neurodegenerative diseases
L10Carbonyl reductaseEnzyme involved in chemotherapy resistance and free radical modulation
L19DNA-dependent ATPase (putative) & X-linked nuclear proteinHelicase involved in transcription initiation and brain differentiation (putative)
L20Homologous with tyrosine kinases???a
L24Hsa2 mitochondrion cytochrome oxidase???a
L25OsteopontinLigand for integrin; involved in adhesion, migration, and osteoclastogenesis
  • a Function not known.