Table 1

Characteristics of human neuroblastoma cell lines sequenced for p53

Cell linep53 statusp53 mutationReferenceMYCN ampaMDM2 ampPre- or posttreatment
SCMC-N-3WT8YesPre
IMR32WT13YesPre
LAN-5WT13YesPre
NBL-SWT14NoPre
CHP212WT15YesPre
SMSKANWT15YesPre
NB-1643WT16YesPre
SKNBE(1n)WTThis articleYesPre
NB-1691WT16YesYesPost
NGPWTbYesYesPost
SKNSHWT13NoPost
CHP134WT13YesPost
SJNB-1WT16NoPost
LAN-1MutantCodon 182, Cys to Stop13YesPost
NMBMutantCodon 245, Gly to Ser14YesPost
SKNBE(2c)MutantCodon 135, Cys to Phe15 and this articleYesPost
SJNB-4MutantCodon 176, Cys to Phe16YesPost
  • a amp, amplification; WT, wild type.

  • b D. A. Tweddle, A. J. Malcolm, M. Cole, A. D. J. Pearson, and J. Lunec. p53 cellular localisation and function in neuroblastoma: evidence for defective G1 arrest despite WAF1 induction in MYCN amplified cells, submitted for publication.