Table 1

Effect of resveratrol on percentage of incidence of atypical ductal lesions in mouse mammary organ culturea

GroupNormal regionsHyperplastic lesionsAtypical lesions
DMBA37.0 ± 8.123.4 ± 6.839.6 ± 11.1
DMBA + resveratrol (10 μm)79.2 ± 15.4 (<0.001)15.3 ± 1.5 (<0.01)5.5 ± 0.2 (<0.001)
DMBA + resveratrol (5 μm)79.4 ± 23.6 (<0.001)16.2 ± 5.1 (<0.01)4.9 ± 1.0 (<0.001)
DMBA + resveratrol (2.5 μm)43.5 ± 12.3b18.4 ± 2.5b38.1 ± 7.8b
DMBA + resveratrol (1 μm)31.5 ± 12.1b26.8 ± 4.5b41.7 ± 12.7b
  • a Values represent the mean percentage of each region in total glands that were classified as normal, hyperlastic, and aggressive, as defined in “Materials and Methods” ± SEs (n = 10). Numbers shown in parentheses are Ps of a two-tailed t test for independent samples.

  • b Not significantly different from the control group that received only DMBA.