Table 2A

Mutual inactivation of p16/Rb and p19/p53 in spontaneous tumors

p16Ink4a-Rb lesionp19ARF-mdm2-p53 lesion
p53+/+p16Ink4a+/+0/11/1
p16Ink4a+/−9/106/10
p16Ink4a−/−7/74/7
Total16/1811/18
p53−/−p16Ink4a+/+3/44/4
p16Ink4a+/−4/1111/11
p16Ink4a−/−2/22/2
Total9/1717/17