Table 2

Fecal excretion of unchanged drug and metabolites after oral administration of docetaxel (10 mg/kg) with or without oral ritonavir (12.5 mg/kg) to wild-type and Mdr1a/1b (−/−) mice

Data are expressed as percentage of administered dose ± SE (n = 4).

Mouse strainRitonavirDocetaxelMetabolites
Wild-type37.8 ± 3.622.5 ± 1.6
Wild-type+65.3 ± 2.73.6 ± 0.6
Mdr1a/1b (−/−) 1.1 ± 0.428.6 ± 2.6
Mdr1a/1b (−/−) +5.5 ± 1.546.0 ± 4.0