Table 4

Forward stepwise multiple logistic regression analysis of pre- and postoperative prognostic parameters and HA, HYAL1, and combined HA-HYAL1 staining inferences

The significant parameters (P < 0.05) selected by the model are shown. A, in the analysis, HA and HYAL1 staining inferences were included separately, along with other pre- (i.e., age, PSA, and clinical stage) and post- [i.e., Gleason sum (or stratified Gleason as ≥7 and <7), EPE, margin +/−, and seminal vesicle invasion] surgery parameters. B, combined HA-HYAL1 staining inference was included in the analysis, together with the above-mentioned pre- and postoperative parameters.

ParameterAB
χ2P valueOR95% CIaχ2P valueOR95% CI
EPE15.200.0023b33.4833.493–320.9129.2710.0023b35.9443.583–360.565
Margin7.5730.0059b26.9482.58–281.4636.8950.0086b24.4382.249–265.55
HYAL16.8460.0094b12.4231.856–83.158NANANANA
HA-HYAL1NANANANA8.6280.0033b18.0472.619–124.378
  • a CI, confidence interval; NA, not applicable.

  • b Statistically significant.