Table 3

Summary of statistical indices for single and multiple marker combination

Marker combinationCPCaCPOOPOOPCAmbiguousSensitivitySpecificityPPVNPVAccuracyPearson χ2Likelihood ratio χ2RSquarePN
CoOvCoOvCoOvCoOvCoOv
1 Marker
  Villin712336NANA0.970.850.850.970.920.940.940.920.9379.387.30.60<0.0001112
  Moesin656288NANA0.920.780.780.920.890.820.820.890.8753.054.50.40<0.0001107
  CK76312381NANA0.840.970.970.840.980.760.760.980.8969.181.10.55<0.0001114
  CK20639351NANA0.880.970.970.880.980.800.800.980.9171.482.60.60<0.0001108
2 Markers
  Villin/moesin601252690.980.930.930.980.970.960.960.970.9774.482.40.76<0.0001103
  Villin/CK7602310970.971.001.000.971.000.940.941.000.9884.5103.30.87<0.0001109
  Villin/CK20581301950.980.970.970.980.980.970.970.980.9881.496.90.84<0.0001104
  Moesin/CK75432811170.950.970.970.950.980.900.900.980.9569.580.20.73<0.0001104
  Moesin/CK205312611270.980.960.960.980.980.960.960.980.9875.684.60.76<0.0001100
  CK7/CK205333401520.951.001.000.951.000.920.921.000.9778.398.50.83<0.0001107
3 Markers
  Villin/moesin/CK752125013110.981.001.000.981.000.960.961.000.9973.689.40.91<0.0001102
  Villin/moesin/CK2049123113100.980.960.960.980.980.960.960.980.9765.275.10.81<0.000197
  Villin/CK7/CK205112901670.981.001.000.981.000.970.971.000.9976.896.90.92<0.0001104
  Moesin/CK7/CK204612601880.981.001.000.981.000.960.961.000.9968.886.50.91<0.000199
4 Markers
  CK7/CK20/villin/moesin44123018110.981.001.000.981.000.960.961.000.9963.778.70.90<0.000197
  • a CPC, colon predicted as colon; CPO, colon predicted as ovary; OPO, ovary predicted as ovary; OPC, ovary predicted as colon; Ambiguous, cases that are not unanimous for all markers (i.e., both colon and ovarian markers are positive); PPV, positive predictive value; NPV, negative predictive value. All calculations were done without ambiguous cases. Sensitivity (Co) = CPC/(CPC + CPO), Specificity (Co) = OPO/(OPC + OPO), PPV (Co) = CPC/(CPC + OPC), NPV = OPO/(CPO + OPO). Note that Specificity (Co) = Sensitivity (Ov) and PPV (Co) = NPV (Ov), Accuracy = (CPC + OPO)/(CPC + CPO + OPO + OPC), P, P of Fisher’s exact test; N, total informative cases; NA, not applicable. Because of missing data, values of N differ.