Table 1

Genes differentially expressed by RASSF1A in NSCLC cell line A549

GenBank accession no.Unigene cluster identificationCommon nameAverage fold changeaDescription
Transcription
 U24576Hs.3844 LMO4 2.2Lim domain only 4
 AF017257Hs.85146 ETS-2 2.2Virus oncogene homolog 2 protein (ets-2) gene
 U31913Hs.75305 AIP 0.4Aryl hydrocarbon receptor-interacting protein
 NM_015842Hs.5978 LMO7 0.5LIM domain only 7
 AB007836Hs.25511 TGFB1/1 3.1Transforming growth factor β 1 induced transcript 1
Signaling/Proliferation
 AA099910Hs.291 ENPEP 2.3Glutamyl aminopeptidase
 N94424Hs.82547 RARRES1 3.7RARRES1 retinoic acid receptor responder 1
 D43639Hs.394 AM 2.5Adrenomedullin
 U80811Hs.75794 EDG2 0.5Endothelial differentiation gene 2
 J04026Hs.432922 TXN 0.4Thioredoxin
 X68277Hs.171695 DUSP1 3.0Dual specificity phosphatase 1
 U77914Hs.91143 JAG1 2.8Ligand in NOTCH signaling pathway
 S75725Hs.119206 IGFBP7 3.8Insulin-like growth factor binding protein 7
 U31449Hs.11881 TM4SF4 3.2Transmembrane 4 superfamily, member 4
 U79458Hs.231840 WBP2 0.5WW domain binding protein 2
 AF027205Hs.31439 SPINT2 0.5Serine protease inhibitor, Kunitz-type, 2
 U76702Hs.25348 FSTL3 2.3Follistatin-like 3
 M19154Hs.169300 TGFB2 2.1Transforming growth factor-β2
 AA228119Hs.239138 PBEF 0.5pre-B-cell colony-enhancing factor
 L33930Hs.286124 CD24A 3.2CD24 signal transducer
 NM_002193Hs.1735 INHBB 0.4Inhibin, βB
 X60201Hs.56023 BDNF 3.0Brain-derived neurotrophic factor
 AF009227Hs.172816 NRG1 2.5Neuregulin 1
 U61849Hs.84154 NPTX1 6.8Human neuronal pentraxin 1
 NM_020548Hs.78888 DBI 0.5Diazepam binding inhibitor
 R87460Hs.108080 CSRP1 2.3Cysteine-rich protein 1
Protein synthesis/degradation
 NM_014294Hs.4147 TRAM 3.0Translocating chain-associating membrane protein
 H11775Hs.8265 TGM2 4.6Transglutaminase 2
 R41770Hs.78056 CTSL 0.3Pro-cathepsin L
 NM_004681Hs.155103 EIF1AY 2.5Eukaryotic translation initiation factor 1A, Y chromosome
 D29012Hs.77060 PSMB6 0.5Proteasome (prosome, macropain) subunit, β type, 6
 NM_001908Hs.297939 CTSB 2.0Cathepsin B
 NM_000475Hs.268490 NR0B1 0.3Nuclear receptor subfamily 0, group B, member 1
 AF053233Hs.172684 VAMP8 0.5Vesicle-associated membrane protein 8
Contraction/calcium
 NP_002464Hs.146550 MYH9 2.1Myosin, heavy polypeptide 9, non-muscle
 NM_005980Hs.2962 S100P 0.3S100 calcium-binding protein P
Metabolism
 AA463510Hs.64 SDHB 5.2SDHB succinate dehydrogenase complex, subunit B
 M77693Hs.28491 SSAT 0.5Spermidine/spermine N1-acetyltransferase
 U43944Hs.14732 ME1 0.5Cytosolic NADP(+)-dependent malic enzyme 1
 NM_006356Hs.64593 ATP5H 0.5Homo sapiens ATP synthase, H+ transporting
 NM_001218Hs.5338 CA12 0.3Carbonic anhydrase XII
 AB032261Hs.119597 SCD 0.4Stearoyl-CoA desaturase 1
Cytoskeletal/Cell adhesion
 AA011024Hs.378774 ACTG2 2.1Actin γ2, smooth muscle, enteric
 NM_014000Hs.75350 VCL 2.1Vinculin
 X94991Hs.75873 ZYX 2.5Zyxin
 J05633Hs.149846 ITGB5 0.5Integrin β5 subunit
 M95787Hs.75777 SM22 9.3Transgelin
 M19713Hs.77899 TPM1 3.6Skeletal muscle alpha-tropomyosin
 M34064Hs.161 CDH2 2.4N-cadherin
ECM
 H99607Hs.111779 SPARC 5.3Secreted protein, acidic, cysteine-rich (osteonectin)
 M59040Hs.169610 CD44 2.0Hyaluronic acid receptor
 NM_001150Hs.1239 ANPEP 2.1Alanyl (membrane) aminopeptidase
 L06139Hs.89640 TEK 0.5Receptor protein-tyrosine kinase
Cell cycle
 M90814Hs.83173 CCND3 0.4Cyclin D3
Apoptosis
 NM_004938Hs.153924 DAPK1 0.5Death-associated protein kinase 1
 X86809Hs.194673 PEA15 2.4Phosphoprotein enriched in astrocytes, Mr 15,000
Others
 M90656Hs.151393 GCS 0.4γ-glutamylcysteine synthetase
 AK002040Hs.194720 ABCG2 0.3ATP-binding cassette, sub-family G (WHITE), member 2
 U77970Hs.321164 NPAS2 0.4Neuronal PAS2
 D49387Hs.114670 LTB4DH 0.4Leukotriene b4 12-hydroxydehydrogenase
 AL512758Hs.193235 DKFZp547D155 0.4Hypothetical protein DKFZp547D155
 H59861Hs.2030 THBD 2.3Thrombomodulin
 AF085356Hs.246112 KIAA0788 0.5U5 snRNP-specific protein, Mr 200,000
 AF070616Hs.3618 HPCAL1 0.5Hippocalcin-like 1
 AA135596Hs.79516 BASP1 0.5Brain-abundant signal protein, membrane-attached, 1
 AJ251830Hs.303125 PIGPC1 0.5P53-induced protein
  • a Microarray data obtained using A549 clones V18 (control) and C5 (RASSF1A).