Table 2

Summary of genes down-regulated in both MDA-MB-435 and MCF-7 cells after exposure to CDDO (16 h, 2 μm)

GenBank accession no.FC MCF-7 cellsGene nameFC in MDA-MB-435 cells
Cell cycle
 X59798−7.0Cyclin D1−3.1
 Z36714−2.0Cyclin F−3.3
 M15796−3.3Proliferating cell nuclear antigen−2.3
Transcription
 Z97630−5.7H1 histone family member 0−26.3
 D64142−4.8H1 histone family member X−10.2
 Z83738−4.8H2B histone family member E−2.6
 AA255502−2.0H4 histone family member G−2.3
 AL037557−2.7Polymerase (RNA) II (DNA directed) polypeptide I−2.3
 X75755−3.4Splicing factor arginine/serine-rich 2−2.1
 AJ245416−2.9U6 snRNA-associated Sm-like protein−2.6
 X79865−2.9Mitochondrial ribosomal protein L12−2.6
Apoptosis
 S81914−5.1Immediate early response 3, IEX-1−3.4
 Y07846−2.0GAS2-related on chromosome 22−2.3
Oncogene
 V00568−5.7v-myc avian myelocytomatosis viral oncogene−2.5
 AB019527−2.2Leucine zipper down-regulated in cancer 1−2.0
Transporter
 U81375−5.6Solute carrier family 29 member 1−2.0
 D38076−2.1RAN binding protein 1−2.5
Transcription factor
 AL109701−2.3CREBBP/EP300 inhibitory protein 1−2.2
 L23959−2.6Transcription factor Dp-1−2.0
 AA845349−2.6Thyroid hormone receptor interactor 7−3.9
Cytoskeleton/cell adhesion
 J00314−3.0Tubulin beta polypeptide−4.1
 X02344−2.1Tubulin beta 2−2.1
 M94362−2.6Lamin B2−2.0
 L37747−2.2Lamin B1−3.4
 U53204−2.4Plectin 1 intermediate filament binding protein 500kD−5.3
Metabolism
 Y09008−2.7Uracil-DNA glycosylase−3.1
 U31930−2.2dUTP pyrophosphatase−2.8
 M36067−2.1Ligase I DNA ATP-dependent−2.8
 J04031−3.4Methylenetetrahydrofolate dehydrogenase−2.4
 D78586−2.7Carbamoyl-phosphate synthetase 2−2.1
 U84371−2.3Adenylate kinase 2−2.0
 AF014398−2.8Inositol(myo)-1(or 4)-monophosphatase 2−4.4
 M21154−2.2S-adenosylmethionine decarboxylase 1−2.8
 D63391−2.1Platelet-activating factor acetylhydrolase isoform Ib gamma−2.9
Lipid metabolism
 AF034544−2.07-dehydrocholesterol reductase−2.5
 L00352−3.0Human LDL receptor−3.0
 AI557240−2.6Diazepam binding inhibitor−2.2
Signal transduction
 S62539−8.2Insulin receptor substrate 1−7.7
 M62403−2.1Insulin-like growth factor-binding protein 4−3.1
Others
 D50914−2.2Block of proliferation 1−2.0
 X57351−2.0Interferon induced transmembrane protein 2 (1–8D)−2.1