Table 3

Summary of genes up-regulated in both MDA-MB-435 and MCF-7 cells after exposure to CDDO (16 h, 2 μm)

GenBank accession no.FC in MCF-7Gene nameFC in MDA-MB-435
Cell cycle
 U031066.5Cyclin-dependent kinase inhibitor 1A (p21 Cip1)2.0
 L292193.4CDC-like kinase 13.8
 U618362.3Putative cyclin G1 partial sequence2.2
Transcription/translation
 U494362.1Eukaryotic translation initiation factor 5, elf52.8
Apoptosis
 AI6707882.0Modulator of apoptosis 12.4
Transporter
 U703222.8Karyopherin (importin) beta 22.1
 W2828117.8GABA(A) receptor-associated protein like 18.1
 U834602.0Solute carrier family 31 (copper transporters) member 12.6
 AB0023114.4PDZ domain containing guanine nucleotide exchange factor(GEF) 14.7
Transcription factor
 S6213824.0TLS/CHOP, Gadd153 member of the C/EBP transcription factor11.1
 X525605.5CCAAT/enhancer binding protein (C/EBP) beta2.0
 U202404.6CCAAT/enhancer binding protein (C/EBP) gamma2.4
 X643186.1E4bp4, a member of the basic region/leucine zipper (bZIP) TF2.1
 S682714.8cAMP responsive element modulator=CREM5.6
 AF0968706.8Estrogen-responsive B box protein=B box zinc finger protein family8.5
 M928432.4Zinc finger protein homologous to Zfp-36 in mouse3.0
 AL05016224.0Testis derived transcript (3 LIM domains)3.9
 AF0121082.0Nuclear receptor coactivator 3, steroid receptor2.2
Cytoskeleton/cell adhesion
 L781326.6Lectin galactoside-binding soluble 8 (galectin 8)2.8
 W288074.6Microtubule-associated proteins 1A/1B light chain 33.1
 U323154.6Syntaxin 3A6.6
 U266484.1Syntaxin 5A2.7
Metabolism
 Z82244137.4Heme oxygenase (decycling) 125.8
 L355469.4Glutamate-cysteine ligase modifier subunit4.8
 M906564.2Glutamate-cysteine ligase catalytic subunit2.5
 U439444.3Malic enzyme 1 NADP(+)-dependent cytosolic2.0
 AL0494173.5Dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related)2.3
 AF0610163.2UDP-glucose dehydrogenase3.6
 X912472.7Thioredoxin reductase 13.6
 X543262.6Glutamyl-prolyl-tRNA synthetase2.0
 M905162.4Glutamine-fructose-6-phosphate transaminase 14.9
 M776932.1Spermidine/spermine N1-acetyltransferase3.9
Signal transduction
 Y075666.2Ric (Drosophila)-like expressed in many tissues, Ras-like GTPases5.1
 AC0051925.9Interferon-related developmental regulator 12.0
 X682772.5Dual specificity phosphatase 13.5
 J038052.1Protein phosphatase 2 (formerly 2A) catalytic subunit beta isoform2.3
 X806923.3Mitogen-activated protein kinase 62.2
Proteolysis, ubiquitin-proteasome pathway
 Z293313.4Ubiquitin-conjugating enzyme E2H (homologous to yeast UBC8)2.4
 AF055001Homocsleine-inducible endoplasmic reticulum stress-inducible ubiquitin-like domain member 14.7
 U467512.9Sequestosome 1, ubiquitin-binding protein sequestosome 12.8
 AF0120862.9RAN binding protein 2-like 12.2
Heat shock protein
 D638612.6Peptidylprolyl isomerase D (cyclophilin D)=heat shock402.3
 L151892.4Heat shock 70kD protein 9B (mortalin-2)2.3
 X879492.3Heat shock 70kD protein 5 (glucose-regulated protein 78kD)3.0
 M117172.0Heat shock 70 kD protein 1A19.6
 L080692.2DnaJ (Hsp40) homolog subfamily A member 13.3
 D854292.0DnaJ (Hsp40) homolog subfamily B member 16.0
Others
 AF0020203.0Niemann-Pick disease type C12.0
 U780272.7Bruton agammaglobulinemia tyrosine kinase3.3
 AF0391032.7HIV-1 Tat interactive protein 2 30 kDa2.3