Table 3

Summary of peripheral nerve sheath tumors in NF mouse models reviewed at the workshop

Tumor (GEM)GenotypeSource/reference
GEM schwannomas
 INf2+/−:Nf1+/−I. Saotome, C-H. Liu, M. Niwa-Kawakita, M. Giovannini, A. I. McClatchey, unpublished results
P0Cre; Nf2flox/flox; Nf1+/−M. Niwa-Kawakita, M. Giovannini, unpublished results
P0-Sch-Δ(39–121) 24
 IINf2+/−:Nf1+/−I. Saotome, C-H. Liu, M. Niwa-Kawakita, M. Giovannini, A. I. McClatchey, unpublished results
P0Cre; Nf2flox/flox; Nf1+/−M. Niwa-Kawakita, M. Giovannini, unpublished results
Nf2+/−:p53+/−cis 13
GEM neurofibromas
 INf1flox/KO;Krox20-cre+ 21
Nf1−/− chimera 19
 IINf1+/−:p53+/− cisK. M. Reilly, D. A. Loisel, J. Ledger, R. T. Bronson, K. Cichowski, S. Shih, T. Jacks, unpublished results
GEM PNSTa
 IIINf1+/−:p53+/− 19
P0-Sch-Δ(39–121) 24
p53K0/+,Nf1K0/flox;Krox20-cre+L. F. Parada, F. Guignard, Y. Zhu, unpublished results
  • a PNST, peripheral nerve sheath tumor.