Table 3

Relative risk of clone sizes adjusted in multivariate cox models

PredictorsnFollow-up in person-yearsNumber with cancerRR for an x cm clone (95% CI)RR for 5 cm of a clone (95% CI)
p53LOH clone size53167261.23x (1.02–1.49)* 2.82 (1.10–7.34)*
 Segment length1.04 (0.94–1.15)1.22 (0.73–2.01)
Aneuploid/tetraploid size47134241.23 (1.00–1.50)* 2.82 (1.00–7.59)*
 Segment length1.12 (1.02–1.22)* 1.76 (1.10–2.70)*
p53LOH presence260114536 7.37 (2.78–19.55)*** 7.37 (2.78–19.55)***
p53LOH clone size1.27 (1.07–1.49)** 3.30 (1.40–7.34)**
Aneuploid/tetraploid presence260114536 10.63 (4.54–24.91)*** 10.63 (4.54–24.91)***
 Aneuploid/tetraploid size1.35 (1.10–1.65)** 4.48 (1.61–12.23)**
p53LOH presence19185631 14.08 (5.91–35.55)*** 14.08 (5.91–35.55)***
p16LOH clone size1.06 (0.96–1.18)1.34 (0.82–2.29)
p53LOH clone size65222301.29x (1.10–1.50)** 3.57 (1.61–7.59)**
 Aneuploid/tetraploid size1.45 (1.19–1.75)*** 6.41 (2.39–16.41)***
p53LOH clone size2591139361.26 (1.05–1.51)* 3.17 (1.28–7.85)*
p53LOH presence2.94 (0.95–9.08)2.94 (0.95–9.08)
 Aneuploid/tetraploid size1.32 (1.04–1.67)* 4.01 (1.22–12.99)*
 Aneuploid/tetraploid presence 3.69 (1.33–10.26)* 3.69 (1.33–10.26)*
  • NOTE. Each row represents a separate multivariate Cox model. The two relative risks within a row correspond to the two predictors in the multivariate model adjusted for the presence of both. Bold values are statistically significant.

  • * A significant result at P< 0.05.

  • ** A significant result at P< 0.01.

  • *** A significant result at P < 0.001.