Table 5

UGT2B7 genotypes and alleles versus NNAL O-glucuronidating phenotype

NNAL-O-glucuronidating phenotypeaUGT2B7 genotypebUGT2B7 allelec
His268HisHis268TyrTyr268TyrTotal268His268TyrTotal
Lowest211518152136
Low58619182038
High67619191938
Highest512118221436
Total183818747474148
  • a Subjects were stratified by quartiles according to levels of NNAL-O-Gluc formation.

  • b A significantly (P = 0.0044) higher number of subjects from the lowest NNAL-N-glucuronidating activity group contained the UGT2B7268Tyr/UGT2B7268Tyr genotype as compared to subjects from the highest NNAL-N-glucuronidating activity group as determined by the Fisher’s exact test.

  • c A significantly (P = 0.017) higher number of variant UGT2B7268Tyr alleles were from subjects from the slowest NNAL-N-glucuronidating activity group as compared with subjects from the highest NNAL-N-glucuronidating activity group as determined by the χ2 test.