Table 2

Effect of energy restriction (ER) and energy repletion (ER-REP) on the cleavage of poly(ADP-ribose) polymerase 1 (PARP-1)a

Control40% ERER-REP
No. of rats18185
PARP-10.11 ± 0.03b0.18 ± 0.04c0.18 ± 0.02c
89-kDA PARP-10.06 ± 0.01b0.15 ± 0.03c0.05 ± 0.02b
24-kDA PARP-10.04 ± 0.01b0.42 ± 0.06c0.01 ± 0.01d
  • a Only one tumor per rat was evaluated. Each value is expressed in relative density units and is a mean ± SE. Data were evaluated by multivariate analysis of variance as described in “Material and Methods.” PARP-1, intact 113 kDA protein; 89-kDA PARP-1 and 24-kDA PARP-1, the two cleavage products into which the 113 kDA protein is cleaved during apoptosis.

  • b Values within a row with different alphabetical superscripts were statistically different, P < 0.025.

  • c Values within a row with different alphabetical superscripts were statistically different, P < 0.025.

  • d Values within a row with different alphabetical superscripts were statistically different, P < 0.025.