Table 1

FANCF promoter methylation and RNA expression in cervical cancer cell lines

Cell linePromoter hypermethylationExpressionaMitomycin C sensitivity
Normal5-Aza-2′deoxycytidineTrichostatin5-Aza-2′deoxycytidine + Trichostatin
CaSkiNo++++Low
HT-3No++++NDb
SiHaYes+++++++++ND
ME-180Yes+++++++++High
SW756Yes+++++++High
MS751No+++++++++ND
C-4INo+++++High
HeLaNo+++++ND
C-33ANo+++++++ND
  • a Downward arrow, complete lack of or decreased expression compared to expression in normal cervix; +, expression similar to normal cervix; ++ and +++ indicate increased levels of expression.

  • b ND, not done.