Table 3.

AZD2171 inhibition of growth factor–stimulated cellular proliferation

Cell typeGrowth factorIC50 (μmol/L) *, mean ± SENo. independent tests
HUVECVEGF0.0004 ± 0.00026
bFGF0.11 ± 0.019
EGF0.50 ± 0.099
MG63PDGF-AA0.04 ± 0.0073
  • * The effect of AZD2171 on growth factor–stimulated proliferation was examined using human endothelial cells (HUVEC) or MG63 human osteosarcoma tumor cells.