Table 1.

Effect of PDGF-D on renal cell carcinoma grown in the kidney of SCID mice

Cell lineTumor takeKidney weight (g)Kidney weight (mean ± SD)Body weight (mean ± SD)Lung metastasis
IncidenceMedian nodules (range)
SN12C5/50.38, 0.31, 0.24, 0.27, 0.330.31 ± 0.0525.6 ± 0.74/521 (0-106)
Mock5/50.35, 0.37, 0.28, 0.31, 0.320.32 ± 0.0424.9 ± 1.25/532 (0-84)
SN12C-PDGFD5/50.90, 0.53, 0.44, 0.73, 0.300.58 ± 0.21 *18.7 ± 1.75/5>200
  • NOTE: SCID mice (n = 5) were inoculated with SN12C (1 × 106) cells with or without the pdgf-d gene. All mice were sacrificed on day 30. Metastasis to the lung was determined on day 30 after injection.

  • * This is one representative experiment of three.

  • P < 0.05.