Table 1.

Genes with two or more nonsynonymous coding somatic mutations in the primary screen

GeneMutation
ANKK1G2207T R736L, G2290A E764K
ATMG1672T G558*, G2542C E848Q, G6154T E2052*, A7996G T2666A
ATRG4462C A1488P, C6005G A2002G, G6698T S2233I
BRAFG1406C G469A, C1789G L597V
DDR1G1486T A496S, CC2469/2470TT R824W
EPHA3C686A S229Y, C1346T S449F, G2297A G766E
EPHA5G1250A R417Q, G1507A E503K
FGFR2G847A D283N, G870C W290C, G1487C R496T
GPRK5C489A D163E, 874insT 292CGRDPLRLRRPPP*
GUCY2FC1064A S355*, A3155G K1052R
MAP2K4A425T Q142L, 882delG 295SHCMSWPQADFLIQSGIVYLIN*
MGC42105C997T P333S, C1231A P411T
NEK10G2633T R878M, C3344T P1115L
NTRK3C2029T H677Y, CG2161/2162TT R721F
PRKDCG4340T R1447M, G8822C G2941A
PRKWNK2G4856A G1619E, G5933T S1978I
SK681A906T R302S, C1826T S609L
STK11/LKB1C109T Q37*, C109T Q37*, 167delG 57KALTAR*, 842delC 281RSLTC*
TAF1LG2250T L750F, C2284A L762I, A2382C E794D
TRPM6G224T G75V, G3021C W1007C
TTNG4937A G1646D, C7156T L2386F, C21910G L7304V, T34907A L11636Q, G35000A R11667, C74240A T24747N
  • NOTE: Frame-shift mutations are annotated at the amino acid level by describing the first amino acid that is altered with respect to the wild-type sequence followed by the novel predicted translation. Termination codons (*). Missense mutations within canonical kinase domains are in bold.