Table 1.

Genomic regions physically associated with p53

Accession no.GeneProbe position4 h24 h
Mean ratioPMean ratioP
Apoptosis
    NM_138765BAX+438 to +1,5744.31.5e−11nsns
    NM_014417BBC3−1,777 to −1,2626.88.4e−124.82.0e−09
−1,777 to −1,2627.96.2e−135.08.3e−11
−788 to −2775.82.1e−073.72.1e−10
−788 to −2775.88.7e−133.51.2e−10
    NM_004864GDF15−4,185 to −3,6784.83.7e−113.57.7e−10
−131 to +3743.12.7e−08nsns
    NM_052815IER3−189 to +8102.64.4e−08nsns
    NM_021127PMAIP1−781 to −2603.97.0e−082.71.2e−07
−45 to +1,0212.64.4e−08nsns
    NM152877TNFRSF6−765 to −62.11.8e−06nsns
−765 to +4214.64.1e−103.21.4e−08
+14 to +9846.48.3e−084.63.0e−10
+862 to +1,3713.22.3e−082.61.1e−06
    NM_147187TNFRSF10B+220 to +73910.96.3e−127.36.9e−12
Cell cycle/growth regulation
    NM_004060CCNG1−420 to +5845.35.9e−123.93.9e−09
    NM_078467CDKN1A−2,557 to −1,1599.53.8e−137.81.3e−10
−556 to −184.84.4e−103.52.1e−11
+1 to +1,0004.89.1e−112.91.3e−08
+614 to +2,1642.43.8e−10nsns
    NM_001274CHEK1−4,395 to −3,8572.41.7e−07nsns
    NM_014398LAMP3−20 to +9872.22.8e−09nsns
    NM_004073PLK3−945 to −1849.11.9e−126.72.7e−12
    NM_003620PPM1D−1,040 to −262.81.4e−082.22.6e−0.6
+405 to +9973.01.6e−0.72.39.1e−07
    NM_152240WIG1−810 to −22.22.1e−09nsns
+192 to +6942.81.6e−09nsns
DNA damage response/repair
    NM_007306BRCA1−4,067 to −3,5673.38.9e−092.74.7e−07
    NM_001731BTG1−4,976 to −4,3842.29.9e−08nsns
    NM_006763BTG2+1 to +1,0003.64.2e−12nsns
+1 to +1,0003.08.7e−07nsns
    NM_000107DDB2+51 to +9558.61.6e−107.53.1e−11
    NM_001924GADD45A+1 to +9302.92.3e−08nsns
+1,026 to +2,0606.16.7e−123.64.2e−09
    NM_004628XPC−586 to −852.23.5e−07nsns
Stress response
    NM_004024ATF3−304 to +8172.14.0e−08nsns
    NM_024417FDXR+1 to +1,0002.71.1e−10nsns
    NM_000581GPX1−522 to +1,3843.51.8e−102.49.1e−08
    NM_006253PRKAB1−112 to +9424.82.0e−122.64.7e−08
    NM_007233TP53AP1+93 to +8672.28.0e−08nsns
    NM_147184TP53I3−543 to +2122.75.3e−09nsns
Other/unknown
    NM_001153ANXA4−797 to +6542.21.3e−08nsns
    NM_020375C12orf5−245 to +7554.73.6e−122.73.4e−07
    NM_005191CD80−3,501 to −2,7502.17.2e−09nsns
    NM_003512HIST1H2AC−4,966 to −4,3322.84.7e−082.53.8e−06
    NM_000528MAN2B1+1,014 to +2,1512.09.5e−11nsns
    NM_000269NME1−306 to +2394.35.0e−11nsns
    NM_012396PHLDA3−886 to −2473.82.7e−102.62.0e−08
−73 to +1,09312.81.2e−118.12.0e−10
+67 to +99411.03.1e−127.02.8e−10
    NM_004581RABGGTA−41 to +4734.42.5e−102.51.2e−08
    NM_002928RGS16−370 to +6322.34.6e−08nsns
    NM_006513SARS+378 to +1,4393.58.1e−102.45.6e−07
    NM_003039SLC2A5−298 to +8352.63.5e−10nsns
    NM_001252TNFSF7+29 to +9562.16.9e−08nsns
  • NOTE: Genes are grouped by functional classification. Probe positions are relative to the transcriptional start site of the corresponding gene. Mean ratio indicates the average signal from the immunoprecipitation-enriched DNA channel as compared with the average signal of the input control channel. P values are calculated from t tests for this comparison. ns, not significant by our testing criteria (Materials and Methods).