Table 4.

Association between amphiregulin/TGF-α positivity in NSCLC tissues and patients' characteristics (N = 449)

VariablesTotal (N = 449)Amphiregulin statusTGF-α status
Amphiregulin positive (n = 163)Amphiregulin negative (n = 286)PTGF-α positive (n = 301)TGF-α negative (n = 148)P
Gender
    Male310134176<0.001 *223870.001 *
    Female139291107861
Age, y
    <6521577148NS14471NS
    ≥652348613815777
Histologic type
    ADC28578207<0.001 , *170115<0.001 , *
    SCC12161609427
    LCC28199262
    ASC15510114
Dominant histologic subtype (n = 273)
    Papillary218521660.011 *12791NS
    Nonpapillary5523323223
    BAC138271110.004 7860NS
    Non-BAC13548878154
Disease stage
    I + II + IIIA359130229NS248111NS
    IIIB9033575337
pT
    T1 + T2320108212NS217103NS
    T3 + T412955748445
pN
    N0 + N1336114222NS221115NS
    N2 + N311349648033
Smoking history
    Never smoker13925114<0.001 80590.005
    Smoker31013817222189
  • Abbreviations: LCC, large-cell carcinoma; BAC, bronchioloalveolar carcinoma.

  • * P < 0.05 (Fisher's exact test).

  • Adenocarcinoma versus other histology.