Table 5.

Cox proportional hazards model analysis of prognostic factors in patients with advanced NSCLCs who were not treated with gefitinib

VariablesHazard ratio (95% CI)P
Univariate analysis
    Amphiregulin (+/−)1.420 (1.075-1.880)0.013 *
    TGF-α (+/−)1.403 (1.034-1.908)0.029 *
    Age (≧65/<65)1.474 (1.115-1.949)0.006 *
    Gender (male/female)1.600 (1.164-2.193)0.004 *
    Histologic type (others/ADC)1.401 (1.063-1.848)0.017 *
    T factor (T3 + T4 / T1 + T2)1.931 (1.451-2.571)<0.001 *
    N factor (N2 + N3 / N0 + N1)2.882 (2.174-2.882)<0.001 *
Multivariate analysis
    Amphiregulin (+/−)1.078 (0.797-1.456)0.627
    TGF-α (+/−)1.280 (0.929-1.764)0.130
    Age (≧65/<65)1.943 (1.456-2.593)<0.001 *
    Gender (male/female)1.587 (1.120-2.252)0.010 *
    Histologic type (others/ADC)1.133 (0.831-1.543)0.431
    T factor (T3 + T4 / T1 + T2)1.695 (1.261-2.278)0.063
    N factor (N2 + N3 / N0 + N1)3.174 (2.353-4.274)<0.001 *
  • * P < 0.05.