Table 4.

Multivariate survival analysis of AP-2 expression pattern and standard histopathologic variables among primary lesions

VariableHazard ratio (95% CI)P
Tumor infiltrating lymphocytes (absent versus present)3.44 (1.52-7.76)0.003
Breslow depth (>2.00 mm versus ≤2.00 mm)2.18 (1.11-4.25)0.0229
Clark level (IV-V versus I-III)1.57 (0.79-3.13)0.2022
Ulceration (present versus absent)1.29 (0.77-2.17)0.3267
Microscopic satellites (present versus absent)0.96 (0.55-1.70)0.9003
Cytoplasmic by nuclear AP-2 ratio (top 25% versus bottom 75%)2.14 (1.22-3.76)0.0082