Table 1.

Combination therapy substantially reduces liver metastases

GroupTreatmentNo. (%) mice with metastasisGroup comparison P
1 (n = 19)Hamster IgG + rat IgG11 (57.8)
2 (n = 18)Anti-CTLA-4 + rat IgG6 (33.3)0.1383 (vs group 1)
3 (n = 21)Anti-4-1BB + hamster IgG8 (38.1)0.2136 (vs group 1)
4 (n = 22)Anti-CTLA-4 + anti-4-1BB1 (4.5)0.0007 (vs group 1)
0.0174 (vs group 2)
0.0050 (vs group 3)
  • NOTE: Data are summarized from four independent experiments. At least two sections per liver were examined after H&E staining.