Table 1.

Significance of gene mutations on radiosensitivity

Protein (genotype)OrthologuePN
Sensitive strains
    ksr-1(ku68)KSR10.0152,118
    ksr-2(dx27)KSR20.0152,254
    soc-2(ku167)SHOC-20.0421,517
    lin-45(n2520)RAF0.0122,672
    mek-1(ks54)MEK-70.0102,133
    mek-2(ku114)MEK-20.0012,668
    mpk-1(ku1)MAPK-10.0042,194
Nonsensitive strains
    sur-6(ku123)PP2A-B0.2881,681
    pmk-3(ok169)p380.1001,824
    akt-1(ok525)AKT10.4622,075
    akt-2(ok393)AKT20.4431,927
  • NOTE: EGFR signaling pathway mutants. Significance was derived from the comparison of N2 animals (N = 2,658) and the listed strains exhibiting the WT phenotype across dose-response curves postirradiation. N, number of animals analyzed.