Table 1.

Differences in known metabolites between borderline tumors and invasive ovarian carcinomas

MetaboliteFold change (ovarian cancer vs borderline tumor)PPathwayEnzymes involved (selected)
Glycerolphosphate alpha5.30.0058Glycerolipid metabolism
Uracil4.26.20e−06Pyrimidine metabolism1.3.1.2 Dihydropyrimidine dehydrogenase; 2.4.2.4 thymidine phosphorylase;
Hypoxanthine3.80.0033Purine metabolism2.4.2.4 Thymidine phosphorylase
Pyrazine-2,5-bishydroxy3.40.0033
Inositol-2-phosphate3.30.0042Glycerolipid metabolism
Phosphoric acid3.20.0029Glycerolipid metabolism
Glutamic acid30.00018Amino acid metabolism C/N balance
Glycine34.30e−08Gly/Ser/Thr metabolism
Malic acid2.80.0028TCA1.1.1.37 Malate dehydrogenase; 1.1.3.3 malate oxidase
γ-Aminobutyric acid2.70.0042Amino acid metabolism C/N balance1.2.1.3 Aldehyde dehydrogenase (NAD+); 2.6.1.19 GABA transaminase; 4.1.1.15 glutamate decarboxylase
α-Tocopherol 22.50.0083(No biosynthesis in humans)
Glucose-1-phosphate degr.2.50.0025Glycerolipid metabolism
Proline2.33.80e−07Amino acid metabolism
Fumaric acid2.20.0011TCA
Creatine2.20.00069Creatine P breakdown
Cysteine20.006Amino acid metabolism
Butyric acid 2-hydroxy20.0051Propanoate metabolism1.1.1.27 Lactate dehydrogenase
Glycine minor20.00041Gly/Ser/Thr metabolism
Glutamine20.0083Amino acid metabolism C/N balance3.5.1.2 Glutaminase
Threonine1.90.00011Gly/Ser/Thr metabolism
Asparagine1.60.00093Amino acid metabolism
Nonadecanoic acid−1.20.0014Free fatty acid
Stearic acid−1.40.0096Free fatty acid
Heptadecanoic acid−1.40.00073Free fatty acid
Benzoic acid−1.60.00011Phenylalanine metabolism
Lactic acid−2.20.0017Propanoate−,glycolysis, pyruvate metabolism1.1.1.27 Lactate dehydrogenase