Table 1.

Chemoprevention of AFB1-induced hepatocarcinogenesis by the triterpenoid CDDO-Im

Observed data *,Calculated morphometric data
GroupGST-P (foci/cm2)Mean focal area (mm2 × 100)Foci/cm3 liverFocal diameter (μm)
No AFB10.08 ± 0.081.045 ± 5162
AFB110.96 ± 2.265.99 ± 1.25668 ± 142162 ± 21
CDDO-Im (μmol/kg)
    16.70 ± 1.311.43 ± 0.27746 ± 14794 ± 10
    32.30 ± 0.551.11 ± 0.48318 ± 44 75 ± 16
    100.84 ± 0.070.97 ± 0.4186 ± 23 , §133 ± 39
    300.221.4611 , §196
    10000 , §
  • * Mean ± SE, n = 5.

  • An average of 2 cm2 liver tissue was examined per rat.

  • Statistically different (P < 0.05) than the 1 μmol/kg group.

  • § Statistically different (P < 0.05) than the AFB1 group.