Table 2.

Dose-dependent changes in mRNA levels measured by quantitative reverse transcription-PCR in rat liver after treatment with CDDO-Im

GeneFold induction
Dose time1 μmol/kg (6 h)3 μmol/kg (6 h)10 μmol/kg (6 h)30 μmol/kg (24 h)
NQO15.0 *6.6 *8.4 *10.5 *12.2 *
GSTA23.1 *3.6 *4.5 *3.1 *3.8 *
GSTA52.0 *2.0 *2.6 *2.3 *3.4 *
AFAR13.3 *21.7 *37.7 *55.5 *44.7 *
EPHX13.6 *3.9 *5.4 *4.4 *4.0 *
HMOX11.11.32.0 *5.9 *0.9
CYP2C110.71.20.80.7 *0.3 *
  • * P < 0.05 compared with vehicle control.