Table 3.

Microarray analysis of the effect of Nrf2 genotype on expression of phase 2 and antioxidant genes by CDDO-Im in mouse liver

Phase 2 and antioxidant genesDescriptionFold-induction
Wild typeNrf2−/−
Ephx1Epoxide hydrolase 1, microsomal4.92.3
Ftl1Ferritin light chain 12.0 *
Ftl2Ferritin light chain 22.3 *
GclcGlutamate-cysteine ligase, catalytic subunit7.12.6
GclmGlutamate-cysteine ligase, modifier subunit1.9 *
GsrGlutathione reductase 13.7 *
Gsta2Glutathione S-transferase, alpha 291.28.9
Gsta3Glutathione S-transferase, alpha 36.411.3
Gsta4Glutathione S-transferase, alpha 411.52.8
Gstm1Glutathione S-transferase, mu 16.92.6
Gstm2Glutathione S-transferase, mu 23.61.7
Gstm3Glutathione S-transferase, mu 310.6 *
Gstm4Glutathione S-transferase, mu 48.4 *
Gstm6Glutathione S-transferase, mu 64.4 *
Gsto1Glutathione S-transferase, omega 12.83.8
Gstp1Glutathione S-transferase, pi 11.7 *
Gstt1Glutathione S-transferase, theta 1 1.6
Gstt2Glutathione S-transferase, theta 2 2.1
Mgst3Microsomal glutathione S-transferase 32.52.1
Nqo1NAD(P)H dehydrogenase, quinone 16.1 *
Txn1Thioredoxin 11.8 *
Txnrd1Thioredoxin reductase 12.5 *
  • * Not different from vehicle control in Nrf2-disrupted (Nrf2−/−) mice.

  • Not different from vehicle control in wild-type mice.