Table 1.

Effects of DNMT inhibitors on the proliferation of various cancer cell lines

TK6JurkatKG-1HCT116Mean IC20
5-aza-CR0.40.10.40.50.4
5-aza-CdR0.10.050.10.30.1
zebularine201020510
procaine400500400400400
EGCG1020201010
RG1082040202020
  • NOTE: Numbers indicate cell line–specific IC20 concentrations (in μmol/L) that caused a 20% reduction in cell proliferation after 3 days of growth in drug-supplemented medium.