Table 1.

In vitro tumor cell killing activity of EM015

Tumor cell lineTumor typeGenotypeIC50 (μmol/L)
MCF-7BreastHer2+, ER+, PR+1.9
MDA-MB-231BreastER−, PR−, Her23.5
ER-MDA-MB-231BreastER+, PR−, Her22.2
BT474BreastHer2+, ER+, PR+7.0
SK-Br3BreastHer2+, ER+, PR−6.5
T47DBreastHer2−, ER+, PR−4.2
  • Abbreviations: ER, estrogen receptor; PR, progesterone receptor.