Table 2.

In vitro tumor cell killing activity of EM015 in drug-resistant cell lines and their normal counterparts

Tumor cell lineTumor typeDrug resistanceIC50 (μmol/L)Reference
MCF-7BreastParental1.9
MTR-3BreastTamoxifen2.035
CEMT-cell lymphomaParental1.2
CEM/VLB100T-cell lymphomaVinblastine1.536
CEM/VM1-5T-cell lymphomaTeniposide1.037
A2780OvarianParental7.2
A2780/ADROvarianAdriamycin7.538
1A9OvarianParental5.5
1A9/PTX10OvarianPaclitaxel5.026