Table 2.

Effect of ZD1839 on cell cycle distribution

Cell lines%G1%S%G2
L3.6p1
 Control67294
 ZD1839, 1 μmol/L78175
 ZD1839, 10 μmol/L84*10†6
BxPC3
 Control513514
 ZD1839, 1 μmol/L64†23†13
 ZD1839, 10 μmol/L71†20†9
CfPac1
 Control761410
 ZD1839, 1 μmol/L801010
 ZD1839, 10 μmol/L84*7*9*
MiaPaCa-2
 Control731215
 ZD1839, 1 μmol/L741214
 ZD1839, 10 μmol/L76915
Panc-1
 Control631324
 ZD1839, 1 μmol/L621424
 ZD1839, 10 μmol/L631324

NOTE: Cell cycle analysis of cells treated with 1 and 10 μmol/L ZD1839. Cells were stained with propidium iodide after a 24-hour exposure to ZD1839 and analyzed by flow cytometry. Percentages of the total cell population in the different phases of the cell cycle were determined and included. Mean value of at least three experiments are shown.

*P < 0.05.

P < 0.001.