Table 3.

Antitumor activity of ZD1839 against human xenografts in nude mice

Tumor volume (mm3)Tumor weight (g)Body weight (g)

NOTE: L3.6p1 and MiaPaCa-2 human pancreatic cancer cells (1 × 106) were injected s.c. into the dorsal flank area of nude mice. When the tumors reached 0.3 cm3, mice were randomized into two treatment groups of 10 mice each: the first control group received vehicle solution, whereas the second group received 100 mg/kg ZD1839 for 5 d/wk by i.p. injection.

*Mice were sacrificed after 2 weeks of treatment.

†Mice were sacrificed after 4 weeks of treatment.

P < 0.05 compared with control.