Table 3.

Antitumor activity of ZD1839 against human xenografts in nude mice

Tumor volume (mm3)Tumor weight (g)Body weight (g)
MeanRangeMeanRangeMeanRange
L3.6p1
 Control*1,3641,204–1,5241.11–1.124.122.3–25.8
 ZD1839†615.67451–780‡0.20.2–0.2‡24.523.2–25.8
MiaPaCa-2*
 Control1,025868–1,1820.60.5–0.829.827.7–32.2
 ZD18391,0351,033–1,1380.50.4–0.628.127.8–28.3

NOTE: L3.6p1 and MiaPaCa-2 human pancreatic cancer cells (1 × 106) were injected s.c. into the dorsal flank area of nude mice. When the tumors reached 0.3 cm3, mice were randomized into two treatment groups of 10 mice each: the first control group received vehicle solution, whereas the second group received 100 mg/kg ZD1839 for 5 d/wk by i.p. injection.

*Mice were sacrificed after 2 weeks of treatment.

†Mice were sacrificed after 4 weeks of treatment.

P < 0.05 compared with control.