Table 1.

List of high-priority MCRs in the CRC oncogenome

Cytogenetic bandMCRsMCR recurrenceHRF locus
Position (Mb)Size (Mb)Maximum/minimum valueGenesGain (Amp)/loss (Del)
%TC
Gain and amplification
    1q21.1-1q25.2143.18–158.3715.192.894372811 (5)11 (5)
    3q12.1-3q12.3101.56–101.950.382.2253010 (3)14 (4)+
    6p21.2-6q1239.26–41.101.841.96112212 (1)5 (2)+
    6p21.2-6q1241.72–43.001.271.96252313 (1)5 (2)
    6p21.2-6q1250.91–54.323.401.15332313 (2)5 (2)
    6q22.32-6q23.3133.13–135.582.452.18182812 (1)10 (4)
    7p15.2-7p11.244.99–48.463.471.74225425 (5)18 (4)
    7p15.2-7p11.254.41–55.310.900.8175625 (4)19 (5)+
    7q11.23-7q31.1105.26–107.151.891.18164822 (2)16 (6)
    8q22.2-8q22.3100.03–103.643.610.93264323 (8)11 (5)
    8q24.12-8q24.12120.92–121.530.615.5554825 (8)13 (7)+
    8q24.13-8q24.21128.31–129.140.845.2245425 (9)18 (13)+
    8q24.21-8q24.23130.92–136.685.771.15204725 (9)12 (7)
    12p13.33-12p13.310.17–6.676.500.9380247 (1)12 (6)
    12p12.1-12q13.1224.61–27.462.851.5325287 (1)15 (9)
    13q12.11-13q14.1219.14–33.3014.165.081206528 (12)23 (16)
    13q21.33-13q22.372.22–73.150.931.5676228 (12)21 (13)+
    13q32.1-13q3497.47–114.1116.641.371016730 (10)23 (14)
    14q32.2-14q32.2100.06–100.270.211.5042310 (5)8 (1)+
    16q11.2-16q12.145.52–47.131.611.24112811 (2)11 (1)
    16q21-16q23.363.53–65.351.810.95152310 (1)8 (2)
    17p11.2-17q1221.83–23.842.011.1730258 (1)12 (4)
    19p13.3-19p13.30.94–0.980.040.924169 (3)4 (0)
    20p13-20p12.12.26–3.841.580.89404219 (4)14 (8)
    20p11.23-20q11.2325.22–29.524.300.97216324 (15)26 (16)
    20p11.23-20q11.2330.08–30.490.410.9796525 (15)26 (14)+
    20q12-20q13.3355.35–62.377.031.391136626 (15)26 (17)
    22q11.21-22q12.321.54–21.720.180.911662 (1)3 (1)
Loss and deletion
    2p22.1-2p2142.46–47.525.06−1.404584 (2)2 (2)
    4q12-4q13.157.51–57.730.22−1.2253414 (2)13 (7)+
    4q27-4q28.2121.97–129.407.43−1.10343413 (2)14 (8)
    5q15-5q1592.95–94.051.10−0.917208 (1)8 (2)+
    6p25.3-6p24.30.29–0.350.06−0.882194 (1)11 (4)
    8p23.3-8p21.30.18–13.9913.80−1.091524919 (6)20 (9)
    8p21.3-8p1221.60–38.3816.78−1.041344619 (6)17 (7)
    8p12-8p11.2139.08–41.232.16−1.3111257 (2)13 (6)+
    8p11.21-8p11.2142.99–43.170.18−0.905235 (2)13 (5)+
    8q22.3-8q23.1104.51–108.333.82−0.831161 (1)4 (1)
    10q25.2-10q26.11114.82–115.790.97−0.869114 (1)5 (1)+
    10q26.13-10q26.3132.78–133.610.84−1.245104 (1)4 (2)
    12q21.1-12q21.273.73–75.241.51−1.111183 (1)3 (2)
    14q21.2-14q21.244.04–44.650.61−1.5772813 (1)9 (2)+
    14q32.2-14q32.298.93–99.260.33−0.8052812 (1)10 (1)+
    15q21.3-15q24.153.90–72.9719.07−0.911882410 (1)9 (1)
    17q11.2-17q21.130.70–30.920.23−3.40793 (1)4 (1)
    18p11.32-18q11.20.66–2.792.13−1.09114622 (5)14 (9)
    18p11.32-18q11.25.22–14.679.44−1.09774823 (5)15 (9)
    18q23-18q2375.32–76.010.69−1.17156125 (6)23 (16)
    19q13.2-19q13.3147.62–48.550.93−0.9026114 (2)5 (0)
    21p11.2-21q21.39.93–16.176.24−1.36353010 (2)14 (3)